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1
Identification and classification of carcinogens: procedures of the Chemical Substances Threshold Limit Value Committee, ACGIH. American Conference of Governmental Industrial Hygienists.致癌物的识别与分类：美国政府工业卫生学家会议化学物质阈限值委员会的程序
Am J Public Health. 1986 Oct;76(10):1232-5. doi: 10.2105/ajph.76.10.1232.
2
A quantitative analysis of factors affecting PELs and TLVs for carcinogens.致癌物职业接触限值和阈限值影响因素的定量分析。
Risk Anal. 1999 Dec;19(6):1223-34. doi: 10.1023/a:1007051215650.
3
Regulation of occupational carcinogens under OSHA's Air Contaminants Standard.职业安全与健康管理局（OSHA）空气污染物标准下对职业致癌物的监管。
Regul Toxicol Pharmacol. 1990 Dec;12(3 Pt 1):296-308. doi: 10.1016/s0273-2300(05)80065-0.
4
[Vinyl chloride and 1,2-dichloroethane: classification and assessment of carcinogenicity, guidelines, threshold values, and standards developed by national and international entities, organizations, and agencies].[氯乙烯和1,2 - 二氯乙烷：致癌性分类与评估、指南、阈值以及国家和国际实体、组织及机构制定的标准]
Epidemiol Prev. 2001 Jan-Feb;25(1):31-9.
5
TLVs threshold limit values for chemical substances in workroom air adopted by the American Conference of Government Industrial Hygienists for 1973.
J Occup Med. 1974 Jan;16(1):39-49.
6
Scrutinizing ACGIH risk assessments: the trichloroethylene case.审视美国政府工业卫生学家会议的风险评估：三氯乙烯案例
Am J Ind Med. 2003 Aug;44(2):207-13. doi: 10.1002/ajim.10252.
7
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8
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9
Guidelines for the evaluation of chemicals for carcinogenicity. Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment.食品、消费品及环境中化学物质致癌性评估指南。食品、消费品及环境中化学物质致癌性委员会。
Rep Health Soc Subj (Lond). 1991;42:1-80.
10
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本文引用的文献

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Guidelines for documentation of epidemiologic studies. Epidemiology Work Group of the Interagency Regulatory Liaison Group.流行病学研究记录指南。跨部门监管联络小组流行病学工作组
Am J Epidemiol. 1981 Nov;114(5):609-13.
2
The problem of thresholds for chemical carcinogens--its importance in industrial hygiene, especially in the field of permissible limits for occupational exposure.化学致癌物的阈值问题——其在工业卫生中的重要性，特别是在职业接触允许限值领域。
Am Ind Hyg Assoc J. 1980 Oct;41(10):685-92. doi: 10.1080/15298668091425518.
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Carcinogenic risk.致癌风险。
Science. 1983 Aug 26;221(4613):810. doi: 10.1126/science.6879178.
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Models of carcinogenesis.致癌模型。
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The multistep nature of cancer development.癌症发展的多步骤性质。
Cancer Res. 1984 Oct;44(10):4217-23.
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Criteria for evidence of chemical carcinogenicity. Interdisciplinary Panel on Carcinogenicity.
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Asbestos exposure, smoking, and neoplasia.石棉暴露、吸烟与肿瘤形成。
JAMA. 1968 Apr 8;204(2):106-12.
8
Antioxidants and carcinogenesis: butylated hydroxytoluene, but not diphenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxy-N-2-fluorenylacetamide in rats.抗氧化剂与致癌作用：丁基羟基甲苯可抑制大鼠体内由N-2-芴基乙酰胺和N-羟基-N-2-芴基乙酰胺诱导的癌症发生，而二苯胺对苯二胺则无此作用。
Food Cosmet Toxicol. 1973 Apr;11(2):199-207. doi: 10.1016/s0015-6264(73)80486-9.
9
Occupational cancer: a hazard for epidemiologists.职业性癌症：流行病学家面临的一种危害。
Int J Epidemiol. 1985 Mar;14(1):22-31. doi: 10.1093/ije/14.1.22.
10
Biologic evidence for the existence of thesholds in chemical carcinogenesis.化学致癌过程中阈值存在的生物学证据。
Environ Health Perspect. 1978 Feb;22:167-70. doi: 10.1289/ehp.7822167.

致癌物的识别与分类：美国政府工业卫生学家会议化学物质阈限值委员会的程序

Identification and classification of carcinogens: procedures of the Chemical Substances Threshold Limit Value Committee, ACGIH. American Conference of Governmental Industrial Hygienists.

作者信息

Spirtas R, Steinberg M, Wands R C, Weisburger E K

出版信息

Am J Public Health. 1986 Oct;76(10):1232-5. doi: 10.2105/ajph.76.10.1232.

DOI:10.2105/ajph.76.10.1232
PMID:3752326
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1646668/
Abstract

The Chemical Substances Threshold Limit Value Committee of the American Conference of Governmental Industrial Hygienists has refined its procedures for evaluating carcinogens. Types of epidemiologic and toxicologic evidence used are reviewed and a discussion is presented on how the Committee evaluates data on carcinogenicity. Although it has not been conclusively determined whether biological thresholds exist for all types of carcinogens, the Committee will continue to develop guidelines for permissible exposures to carcinogens. The Committee will continue to use the safety factor approach to setting Threshold Limit Values for carcinogens, despite its shortcomings. A compilation has been developed for lists of substances considered to be carcinogenic by several scientific groups. The Committee will use this information to help to identify and classify carcinogens for its evaluation.

摘要

美国政府工业卫生学家会议的化学物质阈限值委员会已经完善了其评估致癌物的程序。文中回顾了所使用的流行病学和毒理学证据类型，并就委员会如何评估致癌性数据展开了讨论。尽管尚未最终确定是否所有类型的致癌物都存在生物学阈值，但委员会将继续制定致癌物允许接触的指导方针。尽管存在缺陷，委员会仍将继续采用安全系数法来设定致癌物的阈限值。现已编制了一份清单，列出了几个科学团体认为具有致癌性的物质。委员会将利用这些信息来帮助识别致癌物并对其进行分类以便评估。