Department of Applied Chemistry, Karunya Institute of Technology and Sciences (Deemed University), Coimbatore 641114, Tamil Nadu, India.
Department of Biochemistry and Biotechnology, Annamalai University, Chidambaram 608002, Tamil Nadu, India.
Int J Pharm. 2023 Aug 25;643:123282. doi: 10.1016/j.ijpharm.2023.123282. Epub 2023 Jul 29.
Newer materials for utilization in multi-directional therapeutic actions are investigated, considering delicate design principles involving size and shape control, surface modification, and controllable drug loading and release. Multi-faceted properties are imparted to the engineered nanoparticles, like magnetism, near-infrared absorption, photothermal efficiency, and suitable size and shape. This report presents nickel sulfide and dysprosium-doped nickel sulfide nanoparticles with poly-β-cyclodextrin polymer coating. The nanoparticles belong to the orthorhombic crystal systems, as indicated by X-ray diffraction studies. The size and shape of the nanoparticles are investigated using Transmission Electron Microscope (TEM) and a particle-size analyzer. The particles show soft ferromagnetic characteristics with definite and moderate saturation magnetization values. The nickel sulfide nanoparticles' in vitro anticancer and antibacterial activities are investigated in free and 5-fluorouracil/penicillin benzathine-loaded forms. The 5-fluorouracil-encapsulation efficiency of the nanoparticles is around 87%, whereas it is above 92% in the case of penicillin benzathine. Both drugs are released slowly in a controlled fashion. The dysprosium-doped nickel sulfide nanoparticles show better anticancer activity, and the efficacy is more significant than the free drug. The nanoparticles are irradiated with a low-power 808 nm laser. The dysprosium-doped nickel sulfide nanoparticles attain a higher temperature on irradiation, i.e., above 59 °C. The photothermal conversion efficiency of this material is determined, and the significance of dysprosium doping is discussed. Contrarily, the undoped nickel sulfide nanoparticles show more significant antibacterial activity. This study presents a novel designed nanoparticle system and the exciting variation of properties on dysprosium doping in nickel sulfide nanoparticles.
研究了可用于多向治疗作用的新型材料，考虑了涉及尺寸和形状控制、表面修饰以及可控药物负载和释放的精细设计原则。工程纳米粒子赋予了多方面的特性，如磁性、近红外吸收、光热效率以及合适的尺寸和形状。本报告介绍了具有聚β-环糊精聚合物涂层的硫化镍和掺镝硫化镍纳米粒子。X 射线衍射研究表明，这些纳米粒子属于正交晶系。使用透射电子显微镜（TEM）和粒径分析仪研究了纳米粒子的尺寸和形状。这些粒子表现出软铁磁特性，具有确定和适中的饱和磁化强度值。研究了游离和载有 5-氟尿嘧啶/青霉素苯海拉明的硫化镍纳米粒子的体外抗癌和抗菌活性。纳米粒子的 5-氟尿嘧啶包封效率约为 87%，而青霉素苯海拉明的包封效率则高于 92%。两种药物均以受控方式缓慢释放。掺镝硫化镍纳米粒子显示出更好的抗癌活性，其疗效比游离药物更为显著。用低功率 808nm 激光照射纳米粒子。掺镝硫化镍纳米粒子在照射时达到更高的温度，即高于 59°C。测定了这种材料的光热转换效率，并讨论了镝掺杂的意义。相反，未掺杂的硫化镍纳米粒子表现出更强的抗菌活性。本研究提出了一种新型设计的纳米粒子系统，以及在硫化镍纳米粒子中掺杂镝所带来的令人兴奋的性质变化。
