Mauritz W, Sporn P, Schindler I, Zadrobilek E, Roth E, Appel W
Anasth Intensivther Notfallmed. 1986 Aug;21(4):212-7.
58 patients with peritonitis and acute renal failure (ARF) were treated either by haemodialysis (HD, n = 22), continuous arteriovenous haemofiltration (CAVH, n = 9), or continuous pump-driven haemofiltration (CPDHF, n = 27). In contrast to HD, which led to severe hypotension in 31.9% of procedures and to cardiac arrest in 3 cases, CPDHF caused neither haemodynamic nor metabolic alterations. Control of uraemia was most effective in the CPDHF group, too. Mean daily BUN and creatinine values fell significantly (p less than 0.005) and remained at 60 mg % and 2.0 mg %, respectively, whereas during HD no significant changes were found. During CAVH serum creatinine showed an insignificant decline, whereas BUN even increased. Despite higher costs CPDHF seems to be a promising alternative to HD or CAVH for treatment of ARF in septic patients, as mortality was lower in the CPDHF group and recovery of renal function occurred in 48.2%, whereas during HD only 27.3% recovered from ARF.
58例患有腹膜炎和急性肾衰竭（ARF）的患者接受了血液透析（HD，n = 22）、持续动静脉血液滤过（CAVH，n = 9）或持续泵驱动血液滤过（CPDHF，n = 27）治疗。与HD不同，HD在31.9%的治疗过程中导致严重低血压，并有3例发生心脏骤停，而CPDHF既未引起血流动力学改变也未引起代谢改变。在CPDHF组中对尿毒症的控制也最为有效。平均每日血尿素氮（BUN）和肌酐值显著下降（p < 0.005），分别维持在60mg%和2.0mg%，而在HD期间未发现显著变化。在CAVH期间，血清肌酐呈无显著意义的下降，而BUN甚至升高。尽管成本较高，但CPDHF似乎是治疗脓毒症患者ARF的一种有前景的替代HD或CAVH的方法，因为CPDHF组的死亡率较低，48.2%的患者肾功能恢复，而在HD期间只有27.3%的患者从ARF中恢复。
