Mauritz W, Sporn P, Redl G, Schindler I, Zadrobilek E
Acta Med Austriaca. 1985;12(3-4):83-7.
During a period of 3 years 27 patients in acute renal failure (ARF) due to peritonitis underwent pump driven continuous hemofiltration (PDHF). PDHF caused neither hemodynamic nor metabolic disturbances, which in contrary are frequently seen during intermittent hemodialysis treatment in septic patients. BUN and creatinine levels fell significantly (p less than 0.001) and remained at 60 mg% and 2.0 mg%, respectively (mean values). Severe coagulation disorders occurred in 5 patients; in 2 patients PDHF was continued under protamine administration into the venous line, in 3 patients PDHF was stopped for 24 hours and than started again. Bleeding stopped in all cases, therefore surgery was not necessary. Other major complications of PDHF were not observed. Kidney function recovered in 44.4% of patients, and mortality was 70.4%. This is clearly lower than in abdominal septic patients under intermittent hemodialysis. Despite much higher costs (2.5 times the costs of hemodialysis treatment per day) PDHF seems to be a promising alternative in the treatment of ARF complicating septic multiple organ failure.
在3年期间，27例因腹膜炎导致急性肾衰竭（ARF）的患者接受了泵驱动连续性血液滤过（PDHF）治疗。PDHF既未引起血流动力学紊乱，也未导致代谢紊乱，而在脓毒症患者的间歇性血液透析治疗过程中，这些情况却很常见。尿素氮（BUN）和肌酐水平显著下降（p<0.001），平均值分别维持在60mg%和2.0mg%。5例患者出现严重凝血功能障碍；2例患者在向静脉管路中注入鱼精蛋白的情况下继续进行PDHF治疗，3例患者暂停PDHF 24小时后再次开始治疗。所有病例出血均停止，因此无需进行手术。未观察到PDHF的其他主要并发症。44.4%的患者肾功能恢复，死亡率为70.4%。这明显低于接受间歇性血液透析的腹部脓毒症患者。尽管费用高得多（每天是血液透析治疗费用的2.5倍），但PDHF似乎是治疗并发脓毒症多器官功能衰竭的ARF的一种有前景的替代方法。
