Buranasinsup Shutipen, Bunyaratavej Narong
J Med Assoc Thai. 2015 Sep;98 Suppl 8:S16-20.
Osteocalcin (OC) or bone Gla protein (BGP), a bone specific protein, is one of circulating biomarkers that can be used to determine the quality of bone tissues. It is synthesized by the osteoblast and the odontocyte. The process of OC production requires two types ofvitamin: vitamin D and vitamin K. Vitamin D is requiredfor the production of immature OC or undercarboxylated OC (UcOC) whereas vitamin K is requiredfor the transformation of UcOC to mature OC. In the past, several researchers believed that UcOC was the sensitive marker to determine vitamin K status. In fact, the level of UcOC also depends on vitamin D. This study aims to know the correlation between the levels ofvitamin D and UcOC. The collected data of UcOC and vitamin D levels from 95 healthy volunteers were analyzed. The finding was that there was a weak correlation between UcOC and vitamin D (r = 0.238; p = 0.020) together with UcOC and reciprocal ofvitamin D (r = 0.267; p = 0.009). From this correlation, the serum level of UcOC may be not the real marker for vitamin K.
骨钙素（OC）或骨γ-羧基谷氨酸蛋白（BGP）是一种骨特异性蛋白，是可用于确定骨组织质量的循环生物标志物之一。它由成骨细胞和牙本质细胞合成。OC的产生过程需要两种维生素：维生素D和维生素K。维生素D是产生未成熟OC或未羧化OC（UcOC）所必需的，而维生素K是将UcOC转化为成熟OC所必需的。过去，一些研究人员认为UcOC是确定维生素K状态的敏感标志物。事实上，UcOC的水平也取决于维生素D。本研究旨在了解维生素D水平与UcOC之间的相关性。分析了从95名健康志愿者收集的UcOC和维生素D水平数据。结果发现，UcOC与维生素D之间存在弱相关性（r = 0.238；p = 0.020），UcOC与维生素D的倒数之间也存在弱相关性（r = 0.267；p = 0.009）。基于这种相关性，UcOC的血清水平可能不是维生素K的真正标志物。
