Sun Xiao, Zhang Pan, Ye Zi, Li Lei, Li Qian, Zhang Huimin, Liu Bingxin, Gui Lin
Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
School of Future Technology, University of Chinese Academy of Sciences, Beijing 100039, China.
ACS Biomater Sci Eng. 2023 Dec 11;9(12):6915-6925. doi: 10.1021/acsbiomaterials.3c00710. Epub 2023 Aug 1.
Drug delivery systems based on porous soft biomaterials have been widely reported because of stimuli-responsive drug release and their inherent reservoirs for drug storage. Especially, magnetic-responsive porous soft biomaterials achieve rapid and real-time control of drug release due to the magnetic field-triggered large deformation. However, the drug release profiles of these materials are difficult to predict and repeat, which restrict them from releasing drugs in the required dosage. Here, we report a soft capsule based on a flexible hard-magnetic elastomer foam (HEF) for magnetically controlled on-demand drug delivery. The HEF capsule contains an inner HEF and an outer elastomer shell. The HEF exhibits low elastic modulus (10 kPa) and highly interconnected pores (81% interconnected pores). Benefitting from the novel precompressed magnetization, the compressive deformation of HEF reaches 66%. Thus, an adjustable drug release rate ranging from 0.02 to 1.7 mL/min in the HEF capsule is achieved. The deformation-triggered drug release profiles of the HEF capsule under the magnetic field are accurately predicted, allowing 85% accuracy in drug dosage regulation and more than 90% maximum cumulative drug release. Especially, the HEF capsule is proven capable of acting as a soft robot to perform magnetically driven drug delivery in a human stomach model. HEF can potentially serve as a soft robot for biomedical applications in the human body.
基于多孔软生物材料的药物递送系统因其刺激响应性药物释放以及固有的药物储存库而被广泛报道。特别是，磁响应多孔软生物材料由于磁场触发的大变形而实现了药物释放的快速实时控制。然而，这些材料的药物释放曲线难以预测和重复，这限制了它们按所需剂量释放药物。在此，我们报道了一种基于柔性硬磁弹性体泡沫（HEF）的软胶囊，用于磁控按需药物递送。HEF胶囊包含一个内部HEF和一个外部弹性体壳。HEF表现出低弹性模量（10 kPa）和高度互连的孔隙（81%互连孔隙）。受益于新颖的预压缩磁化，HEF的压缩变形达到66%。因此，在HEF胶囊中实现了0.02至1.7 mL/分钟的可调药物释放速率。准确预测了HEF胶囊在磁场下变形触发的药物释放曲线，药物剂量调节精度达85%，最大累积药物释放率超过90%。特别是，已证明HEF胶囊能够作为一个软机器人在人体胃模型中执行磁驱动药物递送。HEF有潜力作为一种用于人体生物医学应用的软机器人。
