The Key Lab of Health Chemistry & Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering & Materials Science, Soochow University, Suzhou 215123, China.
School of Electronic and Electrical Engineering, Wuhan Textile University, Wuhan 430200, China.
ACS Appl Mater Interfaces. 2023 Aug 16;15(32):38644-38652. doi: 10.1021/acsami.3c05895. Epub 2023 Aug 1.
Persistent luminescence nanoparticles (PLNPs) have shown special advantages in areas such as bioimaging, cancer therapy, stress sensing, and photo-biocatalysis. However, the lack of methods for controllable synthesis of PLNPs with uniform morphologies and strong persistent luminescence has seriously hindered the applications of PLNPs. Herein, we reported that modifying the electronic structures of zinc gallogermanate (ZGGO) PLNPs by nonstoichiometric reactions can produce highly uniform nanocubes with controllable size and persistent luminescence. By nonstoichiometric increase of the Ge/Ga ratio in ZGGO, the ZGGO PLNPs were transformed from a mixture of nanocubes and small nanospheres into highly symmetrical and uniform large nanocubes, accompanied by the enhancement of persistent luminescence intensity by about 3.7 times. Moreover, we found that ZGGO PLNPs were responsive to reactive oxygen species (ROS), that is, the persistent luminescence of ZGGO can be quenched by ROS. Autofluorescence-free serum ROS detection was achieved with the developed PLNPs. Further, a biosensing assay for glucose oxidase (GOx) was designed based on the responsiveness of ZGGO PLNPs to HO. This study may pave a new way for better control of PLNPs' size, morphology, and persistent luminescence, and it can further promote the applications of PLNPs in areas ranging from theranostics to solar energy utilization.
持续发光纳米粒子（PLNPs）在生物成像、癌症治疗、压力传感和光生物催化等领域显示出特殊优势。然而，缺乏可控合成具有均匀形态和强持续发光的 PLNPs 的方法严重阻碍了 PLNPs 的应用。在此，我们通过非化学计量反应来修饰锌镓锗酸盐（ZGGO）PLNPs 的电子结构，从而产生具有可控尺寸和持续发光的高度均匀的纳米立方体。通过非化学计量比增加 ZGGO 中的 Ge/Ga 比，ZGGO PLNPs 从纳米立方体和小纳米球的混合物转变为高度对称和均匀的大纳米立方体，同时持续发光强度增强了约 3.7 倍。此外，我们发现 ZGGO PLNPs 对活性氧物种（ROS）有响应，即 ROS 可以猝灭 ZGGO 的持续发光。利用开发的 PLNPs 可以实现无自发荧光的血清 ROS 检测。进一步，基于 ZGGO PLNPs 对 HO 的响应，设计了用于葡萄糖氧化酶（GOx）的生物传感测定法。这项研究可能为更好地控制 PLNPs 的尺寸、形态和持续发光开辟了新途径，并可以进一步推动 PLNPs 在从治疗到太阳能利用等领域的应用。
