Rogers M P, Dubey D, Reich P
Psychosom Med. 1979 Mar;41(2):147-64. doi: 10.1097/00006842-197903000-00008.
In critically reviewing the sources of evidence connecting psyche and brain with the immune system, the authors include a brief review of current knowledge of the immune system, its interactions with the neuroendocrine system, and other factors influencing its regulation. These include developmental stages, aging, rhythmicity, and a variety of exogenous influences. The need for developing further information about normal base lines is emphasized. Against that background, many sources of data demonstrating connections between the central nervous system and the immune system are presented: indirect evidence from clinical and experimental illnesses involving the immune system, and direct changes in either humoral or cellular immunity after natural or experimental stress, conditioning, hypnosis, and direct brain stimulation. Possible mechanisms are discussed, as well as some important methodological issues for further research.
在批判性地审视将心理与大脑和免疫系统联系起来的证据来源时，作者简要回顾了免疫系统的现有知识、其与神经内分泌系统的相互作用以及影响其调节的其他因素。这些因素包括发育阶段、衰老、节律性以及各种外源性影响。强调了获取更多关于正常基线信息的必要性。在此背景下，展示了许多证明中枢神经系统与免疫系统之间存在联系的数据来源：涉及免疫系统的临床和实验性疾病的间接证据，以及自然或实验性应激、条件反射、催眠和直接脑刺激后体液或细胞免疫的直接变化。讨论了可能的机制以及进一步研究的一些重要方法学问题。
