Cáceres Camila, Castillo Macarena, Carrillo Karin, Tapia Cecilia V, Valderrama Gustavo, Maquilón César, Toro-Ascuy Daniela, Zorondo-Rodríguez Francisco, Fuenzalida Loreto F
Facultad de Ciencias de la Salud, Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile.
Dirección Médica, Clínica Dávila, Santiago, Chile.
Endocrinol Diabetes Nutr (Engl Ed). 2023 Aug-Sep;70(7):476-483. doi: 10.1016/j.endien.2023.05.014. Epub 2023 Jul 30.
The prevalence of obesity has increased dramatically in children worldwide. Obesity has been recognized as a risk factor for more serious viral respiratory infections, mainly in adults.
To study the relationship between overnutrition (obesity and overweight) and clinical severity in children hospitalized with acute respiratory infections of viral origin.
One hundred and forty-three clinical records of children between 2 and 18 years old hospitalized for acute respiratory infection at Clínica Dávila (2014-2018) were analyzed, recording the respiratory viruses detected at the time of hospitalization, weight, and height. Nutritional status was estimated using Z score or body mass index, according to age.
Eighty-tree3 children (58%) were positive for more than one respiratory virus. The main virus detected in monoinfection was adenovirus (9.8%), followed by respiratory syncytial virus (7.7%) and parainfluenza virus (7.7%). There were no deaths. Patients with obesity presented more days of hospitalization (P = .04), oxygen therapy (P = .03) and mechanical ventilation (P < .001), as well as a higher probability of requiring mechanical ventilation (P = .001) and of ICU admission (P = .003) compared with children with normal weight. Patients with overweight presented more days of mechanical ventilation (P < .001) than patients with normal weight. No significant differences were found between the presence of viral coinfection and nutritional status.
Overnutrition is associated with greater severity of viral respiratory infection in hospitalized children.
全球儿童肥胖症的患病率急剧上升。肥胖已被公认为更严重的病毒性呼吸道感染的危险因素，主要发生在成年人中。
研究营养过剩（肥胖和超重）与因病毒性急性呼吸道感染住院儿童的临床严重程度之间的关系。
分析了2014年至2018年在达维拉诊所因急性呼吸道感染住院的143名2至18岁儿童的临床记录，记录住院时检测到的呼吸道病毒、体重和身高。根据年龄，使用Z评分或体重指数评估营养状况。
83名儿童（58%）检测出一种以上呼吸道病毒呈阳性。单一感染中检测到的主要病毒是腺病毒（9.8%），其次是呼吸道合胞病毒（7.7%）和副流感病毒（7.7%）。无死亡病例。与体重正常的儿童相比，肥胖患者住院天数更多（P = 0.04）、接受氧疗的天数更多（P = 0.03）、接受机械通气的天数更多（P < 0.001），以及需要机械通气的概率更高（P = 0.001）和入住重症监护病房的概率更高（P = 0.003）。超重患者接受机械通气的天数比体重正常的患者更多（P < 0.001）。在病毒合并感染的存在与营养状况之间未发现显著差异。
营养过剩与住院儿童病毒性呼吸道感染的更严重程度相关。
