Mustari Akash P, Agarwal Ishan, Das Anupam, Vinay Keshavamurthy
From the Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Dermatology, IMS and SUM Hospital, Bhubaneshwar, Orissa, India.
Indian J Dermatol. 2023 May-Jun;68(3):303-312. doi: 10.4103/ijd.ijd_560_22.
The cutaneous microflora consists of various microorganisms which interact with host epithelial cells and innate and acquired immunity. This microbial milieu and its interaction with host cells prevent the growth of pathogenic organisms and educate host immunity to fight against harmful microorganisms. The microbial composition depends on various intrinsic and extrinsic factors and an imbalance in the cutaneous microflora predisposes the individual to both infectious and non-infectious diseases. Even though probiotics have been extensively studied in various diseases, their efficacy and safety profile are still unclear. A better understanding of the cutaneous microflora is required to develop newer therapeutic targets. In this review, we describe the commensal microbiome and its variation, the current role of the cutaneous microbiome in the pathogenesis of various dermatological diseases, and their therapeutic implications.
皮肤微生物群由多种微生物组成，这些微生物与宿主上皮细胞以及先天性和获得性免疫相互作用。这种微生物环境及其与宿主细胞的相互作用可阻止致病生物的生长，并引导宿主免疫以对抗有害微生物。微生物组成取决于多种内在和外在因素，皮肤微生物群的失衡会使个体易患感染性和非感染性疾病。尽管益生菌已在各种疾病中得到广泛研究，但其疗效和安全性仍不明确。需要更好地了解皮肤微生物群以开发新的治疗靶点。在本综述中，我们描述了共生微生物组及其变异、皮肤微生物组在各种皮肤病发病机制中的当前作用及其治疗意义。
