Maie O, Schneider B V
Arch Dermatol Res. 1986;278(5):398-406. doi: 10.1007/BF00418170.
As only few previous investigations considered size-dependent differences in the histology of congenital nevocytic nevi (CNN) or focused on their ultrastructure, a light- and electron-microscopic study of six giant and six medium-sized CNN was performed. Histologically, giant CNN showed minimal junctional nevus elements and a pandermal, diffuse nevus cell extension including the subcutaneous tissue, while medium-sized CNN exhibited more abundant junctional nests and a rather focal pattern of nevus cell extension into the reticular dermis. Ultrastructurally, giant CNN often showed nevus cells with irregular and indented nuclei and also nevus cells with highly complicated dendrites. Nuclear inclusions, multiple cilia and centrioles, and collagen phagocytosis in nevus cells were found in both groups of CNN. Direct contacts between nevus cells and nerve fibers were observed in medium-sized CNN only. The findings provided no clear morphological indication why giant CNN have a higher risk for malignant degeneration than medium-sized CNN or acquired nevocytic nevi (ANN). On the other hand, the histological differences speak in favor of a different ontogenesis of the various size classes of CNN and ANN.
由于之前只有少数研究考虑过先天性黑素细胞痣（CNN）组织学上的大小依赖性差异或专注于其超微结构，因此对六个巨大型和六个中型CNN进行了光镜和电镜研究。组织学上，巨大型CNN显示交界痣成分极少，痣细胞呈全真皮弥漫性扩展，包括皮下组织，而中型CNN则表现出更多的交界痣巢，且痣细胞向网状真皮的扩展呈局灶性。超微结构上，巨大型CNN常显示细胞核不规则且有凹陷的痣细胞，以及具有高度复杂树突的痣细胞。两组CNN中均发现痣细胞内有核内包涵体、多个纤毛和中心粒，以及胶原吞噬现象。仅在中型CNN中观察到痣细胞与神经纤维之间的直接接触。这些发现没有提供明确的形态学证据来解释为什么巨大型CNN比中型CNN或后天性黑素细胞痣（ANN）具有更高的恶变风险。另一方面，组织学差异表明不同大小类别的CNN和ANN具有不同的发生机制。
