Silvers D N, Helwig E B
J Am Acad Dermatol. 1981 Feb;4(2):166-75. doi: 10.1016/s0190-9622(81)70020-3.
The histologic features of seven congenital nevi within 3 months of birth were studied, together with the ultrastructural features of one of the lesions examined microscopically within 48 hours of birth. All seven lesions showed melanocytic hyperplasia within the epidermis and within pilosebaceous and eccrine sweat units. Nevus cells within the dermis were located in proximity to the adnexae. Melanocytic hyperplasia within the epidermis showed a variety of patterns, at least one of which simulated the atypical melanocytic hyperplasia seen in the superficial spreading type of melanoma. The fine structure of the melanosomes in one case studied by electron microscopy resembled hair-bulb melanosomes. They were distinctly different from melanosomes characteristic of epidermal melanocytes, nevus cells, or melanoma cells.
对出生后3个月内的7个先天性痣的组织学特征进行了研究，并对其中1个在出生后48小时内进行显微镜检查的病变的超微结构特征进行了研究。所有7个病变均显示表皮内以及毛囊皮脂腺和小汗腺单位内有黑素细胞增生。真皮内的痣细胞位于附件附近。表皮内的黑素细胞增生呈现多种模式，其中至少有一种类似于浅表扩散型黑色素瘤中所见的非典型黑素细胞增生。通过电子显微镜研究的1例病例中，黑素小体的精细结构类似于毛球黑素小体。它们与表皮黑素细胞、痣细胞或黑色素瘤细胞特有的黑素小体明显不同。
