一种新型合成类维生素A化合物（一种聚戊烯酸衍生物：E-5166）可抑制紫外线B刺激的表皮鸟氨酸脱羧酶活性。
A novel synthetic vitamin-A-like compound (a polyprenoic acid derivative: E-5166) inhibits UVB-stimulated epidermal ornithine decarboxylase activity.
作者信息
Nemoto O, Koizumi H, Aoyagi T
出版信息
Arch Dermatol Res. 1986;278(5):407-9. doi: 10.1007/BF00418171.
Irradiation of skin with ultraviolet B (UVB) stimulates epidermal activity of ornithine decarboxylase (ODC), a rate limiting polyamine biosynthesing enzyme. The maximum stimulation of ODC activity by UVB was found at 24 after irradiation. Systemic administration of a polyprenoic acid derivative (E-5166) significantly inhibited the UVB-stimulated ODC activity in a dose-dependent manner. The inhibitory effect of E-5166 on the UVB-stimulated ODC activity was found to begin at 5 mg/kg body weight. These results indicate that because it inhibits ODC activity E-5166 can be utilized for the treatment of hyperproliferative skin diseases.
用紫外线B（UVB）照射皮肤会刺激鸟氨酸脱羧酶（ODC）的表皮活性，ODC是一种多胺生物合成限速酶。UVB对ODC活性的最大刺激在照射后24小时出现。多聚戊烯酸衍生物（E-5166）的全身给药以剂量依赖的方式显著抑制UVB刺激的ODC活性。发现E-5166对UVB刺激的ODC活性的抑制作用在体重5mg/kg时开始。这些结果表明，由于E-5166抑制ODC活性，它可用于治疗皮肤过度增殖性疾病。
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