Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam (UvA) and Vrije Universiteit Amsterdam (VU), Amsterdam, The Netherlands.
Oral Dis. 2024 May;30(4):1861-1872. doi: 10.1111/odi.14702. Epub 2023 Aug 2.
This scoping review aims to provide an overview of the research and potential applications of carbon dots (CDs) for oral health purposes.
Systematic literature searches were performed on PubMed and Web of Science databases (up to February 2023). Two co-authors selected the published works independently and extracted the data in accordance with the PRISMA statement. Studies with the application of CDs for oral health purposes were included.
Among 152 articles, 19 articles were finally selected. Eight studies investigated the anti-microbial effects of CDs against, for example, oral pathogens, eight studies explored the applicability of CDs in relation to oral cancer, and three studies investigated CDs in relation to cell differentiation and tissue regeneration in oral health. The studies showed the promising potential of CDs in oral health, particularly for inducing bacterial killing by increasing reactive oxygen species, killing oral cancer cells via photodynamic therapeutic effects, and inducing dental pulp and periodontal bone regeneration.
The findings show that CDs have the potential to be utilized in the future for various oral health purposes. Besides, these results underline the broad-spectrum applicability of CDs, crossing the borders of oral health.
本综述旨在概述用于口腔健康目的的碳点 (CDs) 的研究和潜在应用。
在 PubMed 和 Web of Science 数据库中进行了系统文献检索（截至 2023 年 2 月）。两位合著者独立选择已发表的论文，并根据 PRISMA 声明提取数据。纳入了将 CDs 应用于口腔健康目的的研究。
在 152 篇文章中，最终选择了 19 篇文章。八项研究调查了 CDs 对口腔病原体等的抗菌作用，八项研究探讨了 CDs 在口腔癌方面的适用性，三项研究调查了 CDs 在口腔健康中的细胞分化和组织再生方面的适用性。这些研究表明 CDs 在口腔健康方面具有很大的应用潜力，特别是在通过增加活性氧诱导细菌杀伤、通过光动力治疗效果杀死口腔癌细胞以及诱导牙髓和牙周骨再生方面。
研究结果表明，CDs 有望在未来用于各种口腔健康目的。此外，这些结果强调了 CDs 的广谱适用性，跨越了口腔健康的边界。
