School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India.
School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India.
J Biochem Mol Toxicol. 2023 Nov;37(11):e23482. doi: 10.1002/jbt.23482. Epub 2023 Aug 2.
Inflammation is an essential immune response that helps fight infections and heal tissues. However, chronic inflammation has been linked to several diseases, including cancer, autoimmune disorders, cardiovascular diseases, and neurological disorders. This has increased interest in finding natural substances that can modulate the immune system inflammatory signaling pathways to prevent or treat these diseases. Luteolin is a flavonoid found in many fruits, vegetables, and herbs. It has been shown to have anti-inflammatory effects by altering signaling pathways in immune cells. This review article discusses the current research on luteolin's role as a natural immune system modulator of inflammatory signaling mechanisms, such as its effects on nuclear factor-kappa B, mitogen-activated protein kinases, Janus kinase/signal transducer and activator of transcription, and inflammasome signaling processes. The safety profile of luteolin and its potential therapeutic uses in conditions linked to inflammation are also discussed. Overall, the data point to Luteolin's intriguing potential as a natural regulator of immune system inflammatory signaling processes. More research is needed to fully understand its mechanisms of action and possible therapeutic applications.
炎症是一种重要的免疫反应，有助于对抗感染和修复组织。然而，慢性炎症与多种疾病有关，包括癌症、自身免疫性疾病、心血管疾病和神经退行性疾病。这增加了人们对寻找天然物质的兴趣，这些物质可以调节免疫系统的炎症信号通路，以预防或治疗这些疾病。木樨草素是一种存在于许多水果、蔬菜和草药中的类黄酮。研究表明，木樨草素通过改变免疫细胞中的信号通路具有抗炎作用。这篇综述文章讨论了木樨草素作为天然免疫系统炎症信号机制调节剂的作用的最新研究，例如其对核因子-κB、丝裂原活化蛋白激酶、Janus 激酶/信号转导和转录激活因子以及炎症小体信号通路的影响。还讨论了木樨草素的安全性概况及其在与炎症相关的疾病中的潜在治疗用途。总的来说，数据表明木樨草素作为天然免疫系统炎症信号通路调节剂具有诱人的潜力。需要进一步研究以充分了解其作用机制和可能的治疗应用。
