Yang Liu, Chen Qingxin, Gan Shenglong, Huang Chen, Zhang Huatang, Sun Hongyan
College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, P. R. China.
Department of Chemistry and COSDAF (Centre of Super-Diamond and Advanced Films), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon 999077, Hong Kong, China.
Anal Chem. 2023 Aug 15;95(32):11988-11996. doi: 10.1021/acs.analchem.3c01659. Epub 2023 Aug 2.
Organelle-targeted photosensitizers (PSs) have demonstrated enhanced phototherapeutic effect by specifically destroying subcellular organelle. As a critical cellular organelle, the cell membrane plays crucial roles in maintaining cell integrity and regulating cellular communications. To date, a variety of membrane-targeted PSs have been developed and shown exceptional therapeutic effects. However, functional PSs that can achieve membrane-targeted photodynamic therapy (PDT) and real-time monitor the therapeutic process have rarely been reported. In particular, the development of self-reporting PS with near-infrared (NIR) absorption is highly desirable but remains a challenge. Herein, we presented two molecular rotor-based self-reporting PSs. One of the PSs, , possesses NIR absorption property, making it a promising candidate for clinical applications. These PSs could not only enable membrane-targeted PDT but also demonstrate selective fluorescence response toward viscosity. In this regard, the fluorescence variation of these PSs could be utilized to indicate the disruption of membrane structure during PDT process. By leveraging the feedback of the fluorescence signal, we could make intuitive judgement about the phototherapeutic results. As a result, these two PSs possess significant potential in the field of imaging-guided PDT.
细胞器靶向光敏剂（PSs）已通过特异性破坏亚细胞器展现出增强的光疗效果。作为一种关键的细胞器，细胞膜在维持细胞完整性和调节细胞通讯方面发挥着至关重要的作用。迄今为止，已开发出多种膜靶向PSs，并显示出卓越的治疗效果。然而，能够实现膜靶向光动力疗法（PDT）并实时监测治疗过程的功能性PSs鲜有报道。特别是，开发具有近红外（NIR）吸收的自报告PSs非常必要，但仍然是一项挑战。在此，我们展示了两种基于分子转子的自报告PSs。其中一种PSs具有NIR吸收特性，使其成为临床应用的有前途的候选者。这些PSs不仅能够实现膜靶向PDT，还能对粘度表现出选择性荧光响应。在这方面，这些PSs的荧光变化可用于指示PDT过程中膜结构的破坏。通过利用荧光信号的反馈，我们可以对光疗结果做出直观判断。因此，这两种PSs在成像引导的PDT领域具有巨大潜力。
