Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
People's Hospital of Henan University of Chinese Medicine, Zhengzhou, 450002, China.
Funct Integr Genomics. 2023 Aug 2;23(3):261. doi: 10.1007/s10142-023-01131-y.
As alcohol consumption increases, alcoholic liver disease (ALD) has become more popular and is threating our human life. In this study, we found mulberry fruit extract (MFE) repaired alcohol-caused liver diseases by regulating hepatic lipid biosynthesis pathway and oxidative singling in alcoholically liver injured (ALI) rats. MFE administration inhibited hepatic lipid accumulation and improved liver steatosis in ALI rats. MFE also enhanced the antioxidant capacity and alleviated the inflammatory response by increasing the activities of antioxidant enzymes and decreasing the contents of interleukin (IL)-1β and tumor necrosis factor (TNF)-α. Additionally, MFE regulated the expression of miRNA-155 and lipid metabolism-related PPARα protein in rats. Both miR-155 and PPARα play important roles in liver function. The results indicate that MFE has hepatoprotective effects against ALI in rats.
随着饮酒量的增加，酒精性肝病（ALD）变得越来越普遍，威胁着人类的生命。在这项研究中，我们发现桑椹果提取物（MFE）通过调节肝脂质生物合成途径和酒精性肝损伤（ALI）大鼠的氧化信号来修复酒精引起的肝脏疾病。MFE 给药抑制了肝脂质积累，并改善了 ALI 大鼠的肝脂肪变性。MFE 还通过增加抗氧化酶的活性和降低白细胞介素（IL）-1β和肿瘤坏死因子（TNF）-α的含量，增强了抗氧化能力并减轻了炎症反应。此外，MFE 调节了大鼠中 miRNA-155 和脂质代谢相关的 PPARα 蛋白的表达。miR-155 和 PPARα 都在肝功能中起重要作用。结果表明，MFE 对大鼠的 ALI 具有肝保护作用。
