锂盐对突触体和肾脏匀浆脂质过氧化活性的影响。
Effects of lithium salts on lipid peroxidation activity of synaptosomes and kidney homogenates.
作者信息
Sawas A H, Gilbert J C, Watson M E
出版信息
Arch Int Pharmacodyn Ther. 1986 Jun;281(2):192-7.
PMID:3753101
Abstract
Lithium carbonate increased the lipid peroxidation while lithium sulphate and lithium chloride had no significant effects on lipid peroxidation activity of rat cerebral cortex synaptosomes and kidney homogenates. However, lithium chloride plus sodium carbonate significantly increased the lipid peroxidation activity of kidney homogenates. It is concluded that accompanying anions of lithium salts might play a major role in the increase of lipid peroxidation of both synaptosomes and kidney homogenates.
摘要
碳酸锂增加了脂质过氧化作用，而硫酸锂和氯化锂对大鼠大脑皮质突触体和肾匀浆的脂质过氧化活性没有显著影响。然而，氯化锂加碳酸钠显著增加了肾匀浆的脂质过氧化活性。得出的结论是，锂盐的伴随阴离子可能在突触体和肾匀浆脂质过氧化增加中起主要作用。
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