Sawas A H, Gilbert J C
Arch Int Pharmacodyn Ther. 1985 Aug;276(2):301-12.
Lithium carbonate as well as haloperidol increased lipid peroxidation in rat cerebral cortex synaptosomes and rat kidney homogenates while sulpiride had no significant effects. A combination of lithium carbonate and haloperidol caused a greater increase in lipid peroxidation than did either lithium carbonate or haloperidol alone. It is concluded that the neurotoxic and nephrotoxic effects of lithium carbonate and haloperidol might be a consequence of increased lipid peroxidation in the cerebral cortex and the kidney, respectively.
碳酸锂以及氟哌啶醇均可增加大鼠大脑皮质突触体和大鼠肾脏匀浆中的脂质过氧化作用，而舒必利则无显著影响。碳酸锂与氟哌啶醇联合使用所导致的脂质过氧化增加程度比单独使用碳酸锂或氟哌啶醇时更大。由此得出结论，碳酸锂和氟哌啶醇的神经毒性和肾毒性作用可能分别是大脑皮质和肾脏中脂质过氧化增加的结果。
