氯胺酮对中国仓鼠卵巢细胞的遗传毒性作用。
Genotoxic effects of ketamine on CHO cells.
作者信息
Adhvaryu S G, Trivedi A H, Jani K H, Vyas R C, Dave B J
出版信息
Arch Toxicol. 1986 Jul;59(2):124-5. doi: 10.1007/BF00286736.
PMID:3753193
Abstract
Ketamine, a non-barbiturate anaesthetic agent, was studied for its genotoxic potential using the SCE assay. It was genotoxic in the in vitro system at concentrations comparable to the plasma levels achieved during steady state anaesthesia. It had no effects on cellular kinetics in CHO cells.
摘要
氯胺酮是一种非巴比妥类麻醉剂，使用姐妹染色单体互换试验（SCE试验）对其遗传毒性潜力进行了研究。在体外系统中，当浓度与稳态麻醉期间达到的血浆水平相当时，它具有遗传毒性。它对中国仓鼠卵巢细胞（CHO细胞）的细胞动力学没有影响。
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