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新型猪肠道病毒 G 基因型 2 的特征、系统进化分析及致病性研究

Characterization, phylogenetic analysis, and pathogenicity of a novel genotype 2 porcine Enterovirus G.

机构信息

Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.

Yunnan Animal Science and Veterinary Institute, Yunnan Tropical and Subtropical Animal Virus Diseases Laboratory, Kunming 650224, China.

出版信息

Virus Res. 2023 Oct 2;335:199185. doi: 10.1016/j.virusres.2023.199185. Epub 2023 Aug 10.

DOI:10.1016/j.virusres.2023.199185
PMID:37532142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10448215/
Abstract

Enterovirus G belongs to the family Picornaviridae and are associated with a variety of animal diseases. We isolated and characterized a novel EV-G2 strain, CHN-SCMY2021, the first genotype 2 strain isolated in China. CHN-SCMY2021 is about 25 nm diameter with morphology typical of picornaviruses and its genome is 7341 nucleotides. Sequence alignment and phylogenetic analysis based on VP1 indicated that this isolate is a genotype 2 strain. The whole genome similarity between CHN-SCMY2021 and other EV-G genotype 2 strains is 78.3-86.4%, the greatest similarity is to EVG/Porcine/JPN/Iba26-506/2014/G2 (LC316792.1). Recombination analysis indicated that CHN-SCMY2021 resulted from recombination between 714,171/CaoLanh_VN (KT265894.2) and LP 54 (AF363455.1). Except for ST cells, CHN-SCMY2021 has a broad spectrum of cellular adaptations, which are susceptible to BHK-21, PK-15, IPEC-J2, LLC-PK and Vero cells. In piglets, CHN-SCMY2021 causes mild diarrhea and thinning of the intestinal wall. The virus was mainly distributed to intestinal tissue but was also found in heart, liver, spleen, lung, kidney, brain, and spinal cord. CHN-SCMY2021 is the first systematically characterized EV-G genotype 2 strain from China, our results enrich the information on the epidemiology, molecular evolution and pathogenicity associated with EV-G.

摘要

肠道病毒 G 属于小 RNA 病毒科，与多种动物疾病有关。我们分离并鉴定了一种新型的 EV-G2 株，即中国首例分离的基因型 2 株 CHN-SCMY2021。CHN-SCMY2021 的直径约为 25nm，具有典型的小 RNA 病毒形态，其基因组为 7341 个核苷酸。基于 VP1 的序列比对和系统进化分析表明，该分离株为基因型 2 株。CHN-SCMY2021 与其他 EV-G 基因型 2 株的全基因组相似度为 78.3-86.4%，与 EVG/Porcine/JPN/Iba26-506/2014/G2（LC316792.1）的相似度最高。重组分析表明，CHN-SCMY2021 是由 714,171/CaoLanh_VN（KT265894.2）和 LP54（AF363455.1）之间重组产生的。除 ST 细胞外，CHN-SCMY2021 对 BHK-21、PK-15、IPEC-J2、LLC-PK 和 Vero 细胞具有广泛的细胞适应性。在仔猪中，CHN-SCMY2021 引起轻度腹泻和肠壁变薄。病毒主要分布于肠道组织，但也存在于心脏、肝脏、脾脏、肺脏、肾脏、大脑和脊髓。CHN-SCMY2021 是中国首例系统鉴定的 EV-G 基因型 2 株，我们的研究结果丰富了 EV-G 相关的流行病学、分子进化和致病性信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/6f1dde587a98/gr14.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/6f1dde587a98/gr14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/3622be75cb8c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/d16ab8e5a9c4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/acd22f96a5bc/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/9aa3a923c80b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/9c3011ce4fd8/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/741447d15e33/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/d59698b074b1/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/8f6601368184/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/1cc35bd69537/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/e6263396de32/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/08d6a02a9236/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/66d8f835c945/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/8df84b4cbffd/gr13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af2/10448215/6f1dde587a98/gr14.jpg

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