Pugachev K K, Frank G A, Shimbireva I B, Avdeev G I
Arkh Patol. 1986;48(6):55-60.
Localization of organospecific gastric and intestinal antigens, as well as of carcinoembryonic antigen (CEA) was studied by an indirect immune peroxidase method on the sections of fetal stomach, normal definitive stomach, gastric mucosa with features of superficial and deep gastritis, enterolysis and dysplasia, as well as in gastric tumours. Normally, pepsinogen was found to localize in zymogen cells and to disappear in enterolysis and dysplasia of gastric mucosa. Intestinal antigen is absent from the normal mucosa, but is found in all the cases with enterolysis and dysplasia. CEA is most specific for dysplasia of gastric epithelium. In cancers of intestinal type pepsinogen was found in 54%, intestinal (colonic) antigen in 37.5%, CEA in 62.5%. In diffuse type cancers pepsinogen was absent, intestinal antigen was found in 76.9%, CEA in 92% of tumours.
采用间接免疫过氧化物酶法，对胎儿胃、正常成人胃、具有浅表性和萎缩性胃炎特征的胃黏膜、肠化生及发育异常的组织切片，以及胃肿瘤组织进行了器官特异性胃和肠抗原以及癌胚抗原（CEA）的定位研究。正常情况下，发现胃蛋白酶原定位于胃酶原细胞，在胃黏膜的肠化生和发育异常中消失。正常黏膜中不存在肠抗原，但在所有肠化生和发育异常的病例中均可检测到。CEA对胃上皮发育异常最为特异。在肠型胃癌中，54%的病例可检测到胃蛋白酶原，37.5%可检测到肠（结肠）抗原，62.5%可检测到CEA。在弥漫型胃癌中，胃蛋白酶原缺失，76.9%的肿瘤可检测到肠抗原，92%可检测到CEA。
