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基于无监督域自适应的通用多场景超声图像肿瘤诊断方法。

General Multiscenario Ultrasound Image Tumor Diagnosis Method Based on Unsupervised Domain Adaptation.

机构信息

School of Computing and Artificial Intelligence, Southwest Jiaotong University, Chengdu 611756, P.R. China; Engineering Research Center of Sustainable Urban Intelligent Transportation, Ministry of Education, Chengdu 611756, P.R. China; National Engineering Laboratory of Integrated Transportation Big Data Application Technology, Southwest Jiaotong University, Chengdu 611756, P.R. China; Manufacturing Industry Chains Collaboration and Information Support Technology Key Laboratory of Sichuan Province, Southwest Jiaotong University, Chengdu 611756, P.R. China.

School of Computing and Artificial Intelligence, Southwest Jiaotong University, Chengdu 611756, P.R. China; Engineering Research Center of Sustainable Urban Intelligent Transportation, Ministry of Education, Chengdu 611756, P.R. China; National Engineering Laboratory of Integrated Transportation Big Data Application Technology, Southwest Jiaotong University, Chengdu 611756, P.R. China; Manufacturing Industry Chains Collaboration and Information Support Technology Key Laboratory of Sichuan Province, Southwest Jiaotong University, Chengdu 611756, P.R. China.

出版信息

Ultrasound Med Biol. 2023 Oct;49(10):2291-2301. doi: 10.1016/j.ultrasmedbio.2023.06.015. Epub 2023 Aug 1.

Abstract

OBJECTIVE

The utilization of computer-aided diagnosis (CAD) in breast ultrasound image classification has been limited by small sample sizes and domain shift. Current ultrasound classification methods perform inadequately when exposed to cross-domain scenarios, as they struggle with data sets from unobserved domains. In the medical field, there are situations in which all images must share the same networks as they capture the same symptom of the same participant, implying that they share identical structural content. Nevertheless, most domain adaptation methods are not suitable for medical images as they overlook the common features among the images.

METHODS

To overcome these challenges, we propose a novel diverse-domain 2-D feature selection network (FSN), which uses the similarities among medical images and extracts features with a reconstruction network with shared weights. Additionally, it penalizes the feature domain distance through two adversarial learning modules that align the feature space and select common features. Our experiments illustrate that the proposed method is robust and can be applied to ultrasound images of various diseases.

RESULTS

Compared with the latest domain adaptive methods, 2-D FSN markedly enhances the accuracy of classification of breast, thyroid and endoscopic ultrasound images, achieving accuracies of 82.4%, 96.4% and 89.7%, respectively. Furthermore, the model was evaluated on an unsupervised domain adaptation task using ultrasound images from multiple sources and achieved an average accuracy of 77.3% across widely varying domains.

CONCLUSION

In general, 2-D FSN improves the classification ability of the model on multidomain ultrasound data sets through the learning of common features and the combination of multimodule intelligence. The algorithm has good clinical guidance value.

摘要

目的

计算机辅助诊断(CAD)在乳腺超声图像分类中的应用受到小样本量和领域迁移的限制。当前的超声分类方法在面对跨领域场景时表现不佳,因为它们难以处理未观察到的领域的数据。在医学领域,由于所有图像都必须共享相同的网络,因为它们捕捉到的是同一参与者的同一症状,这意味着它们共享相同的结构内容。然而,大多数领域自适应方法不适合医学图像,因为它们忽略了图像之间的共同特征。

方法

为了克服这些挑战,我们提出了一种新颖的多领域 2D 特征选择网络(FSN),它利用医学图像之间的相似性,使用具有共享权重的重建网络提取特征。此外,它通过两个对抗性学习模块来惩罚特征域距离,使特征空间对齐并选择共同特征。我们的实验表明,所提出的方法是鲁棒的,可以应用于各种疾病的超声图像。

结果

与最新的领域自适应方法相比,2D FSN 显著提高了乳腺、甲状腺和内窥镜超声图像的分类准确性,分别达到 82.4%、96.4%和 89.7%。此外,该模型在使用来自多个来源的超声图像的无监督领域自适应任务中进行了评估,在广泛变化的领域中平均准确率达到 77.3%。

结论

总的来说,2D FSN 通过学习共同特征和组合多模块智能,提高了模型在多领域超声数据集上的分类能力。该算法具有良好的临床指导价值。

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