State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Marine Biomedical Science and Technology Innovation Platform of Lin-gang Special Area, No. 4, Lane 218, Haiji Sixth Road, Shanghai 201306, China.
Molecules. 2023 Jun 30;28(13):5136. doi: 10.3390/molecules28135136.
Phytochemical investigation on the fruits of led to the isolation of five new phragmalin-type limonoids (-) and four known ones (-). The structures of the new compounds -, named chuktabamalins A-E, were elucidated via spectroscopic techniques (HRESIMS, 1D and 2D NMR) and were comparable with the literature data of known compounds. In addition, new compounds were evaluated for in vitro anti-inflammatory activity. Compounds , , and showed moderate anti-inflammatory activity with IC values of 21.72 ± 2.79, 23.29 ± 1.00, 47.08 ± 3.47 and 66.67 ± 2.89 μM, respectively.
对 led 的果实进行的植物化学研究导致分离出了五个新的黄烷素型柠檬苦素（-）和四个已知的（-）。通过光谱技术（HRESIMS、1D 和 2D NMR）阐明了这些新化合物的结构，它们与已知化合物的文献数据相当。此外，还对新化合物进行了体外抗炎活性评估。化合物 、 、 和 表现出中等的抗炎活性，IC 值分别为 21.72±2.79、23.29±1.00、47.08±3.47 和 66.67±2.89 μM。
