Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Institute of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China.
Molecules. 2018 Nov 20;23(11):3024. doi: 10.3390/molecules23113024.
Six new phragmalin limonoids, named moluccensin Z1 (), moluccensin Z2 (), carapanolide Y (), tabulalin N (), chukvelutilide A1 (), and velutinasin J (), as well as two known compounds, chukvelutilide A () and velutinasin D () were isolated from the stems of A. Juss. The structures of the new compounds ⁻ were confirmed by spectroscopic methods, including IR and HRESIMS, as well as 1D and 2D NMR, and by comparisons with the data of known analogues. All compounds were tested for α-glucosidase and acetylcholinesterase inhibitory activities. However, none of the compounds was active against α-glucosidase and acetylcholinesterase in vitro.
从 A. Juss. 的茎中分离得到了 6 种新的石蒜科生物碱，分别命名为 moluccensin Z1()、moluccensin Z2()、carapanolide Y()、tablalin N()、chukvelutilide A1()和 velutinasin J()，以及 2 种已知化合物 chukvelutilide A()和 velutinasin D()。新化合物的结构通过光谱方法，包括 IR 和 HRESIMS 以及 1D 和 2D NMR，并与已知类似物的数据进行比较来确定。所有化合物均进行了α-葡萄糖苷酶和乙酰胆碱酯酶抑制活性测试。然而，在体外实验中，这些化合物均对α-葡萄糖苷酶和乙酰胆碱酯酶没有活性。
