Milovanović Aleksandar P S, Milovanović Andjela, Srebro Dragana, Pajic Jelena, Stanković Sanja, Petrović Tatjana
From the University of Belgrade, Faculty of Medicine; Belgrade, Serbia (A.P.S.M., A.M., D.S., T.P.); Serbian Institute of Occupational Health "Dr Dragomir Karajovic," Belgrade, Serbia (A.P.S.M. J.P., T.P.); Clinic for Rehabilitation, University Clinical Center of Serbia, Belgrade, Serbia (A.M.); University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia (S.S.); and Center for Medical Biochemistry, University Clinical Center of Serbia, Belgrade, Serbia (S.S.).
J Occup Environ Med. 2023 Jul 1;65(7):546-552. doi: 10.1097/JOM.0000000000002848. Epub 2023 Mar 24.
Silicosis is a prevalent incurable pneumoconiosis caused by inhalation of silica dust. Study aimed to investigate inflammatory, hematological, and biochemical parameters as additional biomarkers for diagnosing or monitoring silicosis.
Research enrolled 14 workers with silicosis and 7 healthy controls (without exposure and silicosis). The serum level of prostaglandin E2, C-reactive protein, fibrinogen, biochemical, and hematological parameters were measured. The receiver operating characteristic curve was used to determine diagnostic sensitivity of each biomarker.
Patients with silicosis have a significantly higher level of prostaglandin E2, erythrocyte, hemoglobin, and hematocrit than patients without silicosis. Prostaglandin E2, hemoglobin, and the erythrocyte count are significant in separating the silicosis cases from healthy controls.
Prostaglandin E2 might be an adjuvant peripheral diagnostic biomarker for silicosis, while hematological parameters (erythrocytes, hemoglobin, and hematocrit) might be prognostic biomarkers.
矽肺是一种因吸入二氧化硅粉尘而引发的常见且无法治愈的尘肺病。本研究旨在调查炎症、血液学和生化参数，将其作为诊断或监测矽肺的额外生物标志物。
该研究纳入了14名矽肺患者和7名健康对照者（无接触史且无矽肺）。测量了血清中前列腺素E2、C反应蛋白、纤维蛋白原、生化和血液学参数。采用受试者工作特征曲线来确定每个生物标志物的诊断敏感性。
矽肺患者的前列腺素E2、红细胞、血红蛋白和血细胞比容水平显著高于无矽肺患者。前列腺素E2、血红蛋白和红细胞计数在区分矽肺病例与健康对照方面具有显著性。
前列腺素E2可能是矽肺的辅助外周诊断生物标志物，而血液学参数（红细胞、血红蛋白和血细胞比容）可能是预后生物标志物。
