血清前列腺素E2浓度作为矽肺患者诊断生物标志物的病例对照研究

Serum Concentration of Prostaglandin E2 as a Diagnostic Biomarker in Patients With Silicosis: A Case-Control Study.

作者信息

Milovanović Aleksandar P S, Milovanović Andjela, Srebro Dragana, Pajic Jelena, Stanković Sanja, Petrović Tatjana

机构信息

From the University of Belgrade, Faculty of Medicine; Belgrade, Serbia (A.P.S.M., A.M., D.S., T.P.); Serbian Institute of Occupational Health "Dr Dragomir Karajovic," Belgrade, Serbia (A.P.S.M. J.P., T.P.); Clinic for Rehabilitation, University Clinical Center of Serbia, Belgrade, Serbia (A.M.); University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia (S.S.); and Center for Medical Biochemistry, University Clinical Center of Serbia, Belgrade, Serbia (S.S.).

出版信息

J Occup Environ Med. 2023 Jul 1;65(7):546-552. doi: 10.1097/JOM.0000000000002848. Epub 2023 Mar 24.

DOI:10.1097/JOM.0000000000002848

PMID:36977359

Abstract

OBJECTIVE

Silicosis is a prevalent incurable pneumoconiosis caused by inhalation of silica dust. Study aimed to investigate inflammatory, hematological, and biochemical parameters as additional biomarkers for diagnosing or monitoring silicosis.

METHODS

Research enrolled 14 workers with silicosis and 7 healthy controls (without exposure and silicosis). The serum level of prostaglandin E2, C-reactive protein, fibrinogen, biochemical, and hematological parameters were measured. The receiver operating characteristic curve was used to determine diagnostic sensitivity of each biomarker.

RESULTS

Patients with silicosis have a significantly higher level of prostaglandin E2, erythrocyte, hemoglobin, and hematocrit than patients without silicosis. Prostaglandin E2, hemoglobin, and the erythrocyte count are significant in separating the silicosis cases from healthy controls.

CONCLUSIONS

Prostaglandin E2 might be an adjuvant peripheral diagnostic biomarker for silicosis, while hematological parameters (erythrocytes, hemoglobin, and hematocrit) might be prognostic biomarkers.

摘要