金属基光增敏剂作为调控细胞死亡机制的诱导剂。

Metal-Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms.

机构信息

Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemistry, 75005 Paris, France.

Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory of Synthesis, Electrochemistry, Imaging and Analytical Systems for Diagnosis, 75005 Paris, France.

出版信息

Chem Rev. 2023 Aug 23;123(16):10135-10155. doi: 10.1021/acs.chemrev.3c00161. Epub 2023 Aug 3.

DOI:10.1021/acs.chemrev.3c00161

PMID:37534710

Abstract

Over the last few decades, various forms of regulated cell death (RCD) have been discovered and were found to improve cancer treatment. Although there are several reviews on RCD induced by photodynamic therapy (PDT), a comprehensive summary covering metal-based photosensitizers (PSs) as RCD inducers has not yet been presented. In this review, we systematically summarize the works on metal-based PSs that induce different types of RCD, including ferroptosis, immunogenic cell death (ICD), and pyroptosis. The characteristics and mechanisms of each RCD are explained. At the end of each section, a summary of the reported commonalities between different metal-based PSs inducing the same RCD is emphasized, and future perspectives on metal-based PSs inducing novel forms of RCD are discussed at the end of the review. Considering the essential roles of metal-based PSs and RCD in cancer therapy, we hope that this review will provide the stage for future advances in metal-based PSs as RCD inducers.

摘要

在过去的几十年中，已经发现了各种形式的受调控的细胞死亡（RCD），并发现它们可以改善癌症治疗。尽管有关于光动力疗法（PDT）诱导的 RCD 的几篇综述，但尚未有涵盖基于金属的光敏剂（PSs）作为 RCD 诱导剂的综合总结。在这篇综述中，我们系统地总结了关于诱导不同类型 RCD 的基于金属的 PSs 的工作，包括铁死亡、免疫原性细胞死亡（ICD）和细胞焦亡。解释了每种 RCD 的特征和机制。在每一节的末尾，强调了报告的不同基于金属的 PSs 诱导相同 RCD 之间的常见性总结，并在综述的最后讨论了基于金属的 PSs 诱导新型 RCD 的未来展望。考虑到金属基 PSs 和 RCD 在癌症治疗中的重要作用，我们希望本综述将为未来基于金属的 PSs 作为 RCD 诱导剂的进展提供一个平台。