Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia.
Department of Public Health, Faculty of Applied Medical Sciences, Albaha University, Albaha 65431, Saudi Arabia.
J Infect Public Health. 2023 Sep;16(9):1471-1480. doi: 10.1016/j.jiph.2023.06.016. Epub 2023 Jun 26.
Except for a few preventative Human Papillomavirus (HPV) vaccines, there is currently no cure for HPV infection. There are a number of cutting-edge strategies and potent medications or herbal formulations that can be applied topically for early clearance of HPV infection before HPV DNA gets integrated into host cell genome. This is facilitated due to cervical cancer having distinct and well-recognized long precancerous stages.
This review aims to outline every possible medication and formulation, both natural and synthetic, that can be applied topically as intravaginal application to help remove HPV infection at an early precancerous stage.
Several anti-HPV/HPV clearance compounds and formulations for high-grade lesions are undergoing clinical trials. However, the majority of compounds are still in the early stages of development and require additional research to become viable HPV clearance candidates. Synthetic drugs may be more promising because they may have a more targeted effect; however, they may also have significant adverse effects. On the other hand, natural medications are safer to use. They are less specific, but have minimal to no adverse effects.
This article may serve as a valuable resource of information for managing and preventing precancerous carcinogenic HPV infections. Research could be directed toward developing candidate drugs to make evidence-based decisions about advancing them to clinical trials and, eventually, to the market for potential use in the prevention and control of cervical cancer, which is almost always preventable or even curable if detected early.
除了少数预防性人乳头瘤病毒（HPV）疫苗外，目前还没有治愈 HPV 感染的方法。有许多前沿的策略和有效的药物或草药制剂可以用于早期清除 HPV 感染，防止 HPV DNA 整合到宿主细胞基因组中。这是因为宫颈癌有明确的、公认的长癌前阶段。
本综述旨在概述所有可能的药物和制剂，包括天然和合成的，可作为阴道内应用，以帮助在早期癌前阶段清除 HPV 感染。
一些用于高级别病变的抗 HPV/HPV 清除化合物和制剂正在进行临床试验。然而，大多数化合物仍处于开发的早期阶段，需要进一步的研究才能成为可行的 HPV 清除候选物。合成药物可能更有前途，因为它们可能具有更针对性的作用；然而，它们也可能有显著的不良反应。另一方面，天然药物使用起来更安全。它们的针对性较差，但不良反应最小或没有。
本文可为管理和预防癌前致癌 HPV 感染提供有价值的信息资源。研究方向可以是开发候选药物，以便就将其推进临床试验并最终推向市场用于预防和控制宫颈癌做出基于证据的决策，因为如果及早发现，宫颈癌几乎总是可以预防甚至治愈的。
