Faugere M C, Okamoto S, DeLuca H F, Malluche H H
Am J Physiol. 1986 Jan;250(1 Pt 1):E35-8. doi: 10.1152/ajpendo.1986.250.1.E35.
The effects of calcitriol on histomorphometric parameters of bone structure, formation, and resorption were evaluated in 21 normal or oophorectomized rats. Twelve rats were oophorectomized; six of these received daily subcutaneous injections of 135 pmol of calcitriol for 14 wk starting 38 wk after oophorectomy. Nine rats were sham operated; five of these received the same treatment with calcitriol. There were no differences in serum calcium and phosphorus between sham-operated and oophorectomized animals and rats with or without calcitriol. Calcitriol treatment of sham-operated rats produced an increase in cancellous and cortical bone mass. Oophorectomy resulted in decreased cancellous and cortical bone mass and in a decreased ratio between mineralized and nonmineralized bone. There was no difference in bone-osteoclast interface and osteoid seam width among all groups of rats. Calcitriol corrected, at least in part, the bone loss in oophorectomized animals, normalized the ratio between mineralized and nonmineralized bone, and restored mean growth plate width to normal.
在21只正常或卵巢切除的大鼠中评估了骨化三醇对骨结构、形成和吸收的组织形态计量学参数的影响。12只大鼠接受了卵巢切除术；其中6只在卵巢切除术后38周开始，每日皮下注射135 pmol骨化三醇，持续14周。9只大鼠接受假手术；其中5只接受相同的骨化三醇治疗。假手术组与卵巢切除组以及使用或未使用骨化三醇的大鼠之间，血清钙和磷没有差异。对假手术大鼠进行骨化三醇治疗可使松质骨和皮质骨量增加。卵巢切除术导致松质骨和皮质骨量减少，矿化骨与非矿化骨的比例降低。所有大鼠组之间的骨-破骨细胞界面和类骨质缝宽度没有差异。骨化三醇至少部分纠正了卵巢切除动物的骨质流失，使矿化骨与非矿化骨的比例正常化，并使平均生长板宽度恢复正常。
