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新生儿重症监护病房中的人乳强化策略。

Human Milk Fortification Strategies in the Neonatal Intensive Care Unit.

机构信息

Division of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Division of Neonatology, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, 2015 Uppergate Drive Northeast, Atlanta, GA 30322, USA.

出版信息

Clin Perinatol. 2023 Sep;50(3):643-652. doi: 10.1016/j.clp.2023.04.006. Epub 2023 May 26.

DOI:10.1016/j.clp.2023.04.006
PMID:37536769
Abstract

Multicomponent fortification is the standard of care to support short-term growth in preterm infants receiving human milk. There is no consensus regarding the optimal timing, method, or products used to fortify human milk. Both bovine milk-based and human milk-based human milk fortifiers are safe options, though increased fortification and enrichment may be needed to achieve adequate growth. Additional studies are needed to evaluate newer fortifier products and fortification strategies.

摘要

多种成分强化是支持接受母乳的早产儿短期生长的标准护理。对于最佳强化时机、方法或产品尚未达成共识。牛乳制品和人乳来源的人乳强化剂均为安全选择,但可能需要增加强化和增稠以实现充足的生长。需要进一步研究来评估新的强化剂产品和强化策略。

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Human Milk Fortification Strategies in the Neonatal Intensive Care Unit.新生儿重症监护病房中的人乳强化策略。
Clin Perinatol. 2023 Sep;50(3):643-652. doi: 10.1016/j.clp.2023.04.006. Epub 2023 May 26.
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Human milk-derived fortifier versus bovine milk-derived fortifier for prevention of mortality and morbidity in preterm neonates.人乳强化剂与牛乳强化剂预防早产儿死亡和发病的比较
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Early fortification of enteral feedings for infants <1250 grams birth weight receiving a human milk diet including human milk based fortifier.对于接受包括人乳强化剂在内的人乳喂养、出生体重<1250 克的婴儿,早期强化肠内喂养。
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J Trop Pediatr. 2019 Oct 1;65(5):439-445. doi: 10.1093/tropej/fmy074.

引用本文的文献

1
Osmolality of donor human milk rises dramatically within minutes of fortification with varied degrees depending on the fortifier used.捐赠人乳的渗透压在强化后的几分钟内会急剧上升,上升幅度因所使用的强化剂不同而有所差异。
Front Pediatr. 2025 Jun 6;13:1596255. doi: 10.3389/fped.2025.1596255. eCollection 2025.
2
Improved Growth Velocity Using a New Liquid Human Milk Fortifier in Very Low Birth Weight Infants: A Multicenter, Retrospective Study.使用新型液态人乳强化剂提高极低出生体重儿的生长速度:一项多中心回顾性研究
Am J Perinatol. 2025 Oct;42(13):1729-1737. doi: 10.1055/a-2527-4638. Epub 2025 Jan 29.
3
Narrative review of methodological advances in human milk fortification: for better preterm infant growth.
人乳强化方法学进展的叙述性综述:促进早产婴儿更好地生长
Front Pediatr. 2024 Nov 28;12:1466528. doi: 10.3389/fped.2024.1466528. eCollection 2024.
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Adjusted versus Targeted Fortification in Extremely Low Birth Weight Preterm Infants: Fortin Study-A Randomized Clinical Trial.调整与目标强化在极低出生体重早产儿中的应用:Fortin 研究——一项随机临床试验。
Nutrients. 2024 Aug 30;16(17):2904. doi: 10.3390/nu16172904.