Bailone Ricardo Lacava, Fukushima Hirla Costa Silva, Ventura Fernandes Bianca Helena, De Aguiar Luís Kluwe, Corrêa Tatiana, Janke Helena, Grejo Setti Princia, Roça Roberto De Oliveira, Borra Ricardo Carneiro
Ministry of Agriculture, Livestock and Supply, Federal Inspection Service, São Carlos, SP Brazil.
2São Paulo State University, Botucatu, SP Brazil.
Lab Anim Res. 2020 May 7;36:13. doi: 10.1186/s42826-020-00042-4. eCollection 2020.
Much of medical research relies on animal models to deepen knowledge of the causes of animal and human diseases, as well as to enable the development of innovative therapies. Despite rodents being the most widely used research model worldwide, in recent decades, the use of the zebrafish () model has exponentially been adopted among the scientific community. This is because such a small tropical freshwater teleost fish has crucial genetic, anatomical and physiological homology with mammals. Therefore, zebrafish constitutes an excellent experimental model for behavioral, genetic and toxicological studies which unravels the mechanism of various human diseases. Furthermore, it serves well to test new therapeutic agents, such as the safety of new vaccines. The aim of this review was to provide a systematic literature review on the most recent studies carried out on the topic. It presents numerous advantages of this type of animal model in tests of efficacy and safety of both animal and human vaccines, thus highlighting gains in time and cost reduction of research and analyzes.
许多医学研究依靠动物模型来加深对动物和人类疾病病因的认识，并推动创新疗法的开发。尽管啮齿动物是全球使用最广泛的研究模型，但近几十年来，斑马鱼模型在科学界的使用呈指数级增长。这是因为这种小型热带淡水硬骨鱼与哺乳动物在基因、解剖学和生理学上具有关键的同源性。因此，斑马鱼是行为、遗传和毒理学研究的优秀实验模型，有助于揭示各种人类疾病的机制。此外，它还非常适合测试新的治疗药物，如新疫苗的安全性。这篇综述的目的是对该主题的最新研究进行系统的文献综述。它展示了这种动物模型在动物和人类疫苗的有效性和安全性测试中的诸多优势，从而突出了研究和分析在时间和成本降低方面的成果。
