Gerhard J P, Willard D, Messer J
Graefes Arch Clin Exp Ophthalmol. 1986;224(1):62-3. doi: 10.1007/BF02144137.
Ophthalmoscopic examinations were performed on 5678 prematures, born between 1964 and 1984, by the same investigator in the same neonatal care unit. Three periods can be differentiated. In the first period (1964-1970) retinal disorders were frequent (20%), a quarter of them severe (stages 3-5). The inspiratory fraction of oxygen was the only oxymetric factor that was monitored. In the second period (1970-1977), less severe forms were observed, but still 4.5% of stage 1 and 8.7% of stage 2 (mild forms) were assessed. During this period, oxygen partial pressure was measured every 6 h in arterial blood whenever the inspiratory fraction of oxygen exceeded 0.3. In the last period (1977-1984), no severe forms were observed and mild forms amounted to only 0.9%. In this period, oxygen partial pressure was continuously monitored transcutaneously, whenever the inspiratory fraction of oxygen exceeded 0.21. Such data show that there is an association between better oxygen monitoring and the dramatically reduced incidence of retinopathy in prematures (RP).
1964年至1984年间，同一位研究者在同一新生儿重症监护病房对5678名早产儿进行了眼底检查。可分为三个阶段。在第一阶段（1964 - 1970年），视网膜疾病很常见（20%），其中四分之一病情严重（3 - 5期）。仅监测了吸氧分数这一血氧测定因素。在第二阶段（1970 - 1977年），观察到病情较轻的病例，但仍有4.5%为1期，8.7%为2期（轻度病例）。在此期间，每当吸氧分数超过0.3时，每6小时测量一次动脉血氧分压。在最后阶段（1977 - 1984年），未观察到严重病例，轻度病例仅占0.9%。在此期间，每当吸氧分数超过0.21时，就通过经皮方式持续监测血氧分压。这些数据表明，更好的氧监测与早产儿视网膜病变（RP）发病率的显著降低之间存在关联。
