Department of Pharmacy, Banasthali Vidyapith, Rajasthan, India.
R & D, Patanjali Ayurved Ltd, Patanjali Food and Herbal Park, Haridwar, Uttarakhand, India.
Phytother Res. 2022 Aug;36(8):3143-3180. doi: 10.1002/ptr.7522. Epub 2022 Jul 4.
Curcumin, isolated from turmeric (Curcuma longa L.) is one of the broadly studied phytomolecule owing to its strong antioxidant and anti-inflammatory potential and has been considered a promising therapeutic candidate in a wide range of disorders. Considering, its low bioavailability, different curcumin analogs have been developed to afford desired pharmacokinetic profile and therapeutic outcome in varied pathological states. Several preclinical and clinical studies have indicated that curcumin ameliorates mitochondrial dysfunction, inflammation, oxidative stress apoptosis-mediated neural cell degeneration and could effectively be utilized in the treatment of different neurodegenerative diseases. Hence, in this review, we have summarized key findings of experimental and clinical studies conducted on curcumin and its analogues with special emphasis on molecular pathways, viz. NF-kB, Nrf2-ARE, glial activation, apoptosis, angiogenesis, SOCS/JAK/STAT, PI3K/Akt, ERK1/2 /MyD88 /p38 MAPK, JNK, iNOS/NO, and MMP pathways involved in imparting ameliorative effects in the therapy of neurodegenerative disorders and associated conditions.
姜黄素是从姜黄（Curcuma longa L.）中分离出来的一种植物分子，由于其强大的抗氧化和抗炎潜力，已成为广泛研究的对象，并被认为是多种疾病有前途的治疗候选物。考虑到其生物利用度低，已经开发出了不同的姜黄素类似物，以在各种病理状态下提供所需的药代动力学特征和治疗效果。一些临床前和临床研究表明，姜黄素可改善线粒体功能障碍、炎症、氧化应激、凋亡介导的神经细胞退化，并可有效用于治疗不同的神经退行性疾病。因此，在本综述中，我们总结了关于姜黄素及其类似物的实验和临床研究的关键发现，特别强调了参与赋予神经退行性疾病及其相关病症治疗改善效果的分子途径，即 NF-kB、Nrf2-ARE、神经胶质细胞激活、细胞凋亡、血管生成、SOCS/JAK/STAT、PI3K/Akt、ERK1/2 /MyD88 /p38 MAPK、JNK、iNOS/NO 和 MMP 途径。
