一种用于核酸序列比较分析的计算机程序。
A computer program for comparative analysis of nucleic acid sequences.
作者信息
Blanz P A, Kleindienst S
出版信息
Nucleic Acids Res. 1986 Jan 10;14(1):537-41. doi: 10.1093/nar/14.1.537.
The programs offer the possibility of comparing pairs of homologous sequences in order to find out percentage of homology, number of identical and deviating nucleotides, of transitions and transversions and, derived from these, KNUC-values according to Kimura (1) and the corresponding standard error sigmaK. The sequences can be printed in pairs underneath each other, homologies are indicated by asterisks between the identical nucleotides. Out of a set of homologous sequences stored on a disk any number of sequences can be compared in pairs in this way, and a matrix containing either the percentage of homology values, the number of deviating nucleotides or the KNUC-values together with the corresponding standard errors can be sent to screen, printer or disk. A program will be available soon which creates a dendrogram representing the similarity between the sequences by use of an average linkage clustering method deduced from this matrix. The programs are written for Apple II computers using UCSD-PASCAL and for Sirius I/Victor 9000 computers using TURBO-PASCAL.
这些程序提供了比较同源序列对的可能性，以便找出同源性百分比、相同和不同核苷酸的数量、转换和颠换的数量，并由此得出根据木村（1）计算的KNUC值以及相应的标准误差sigmaK。序列可以成对打印在彼此下方，同源性由相同核苷酸之间的星号表示。通过这种方式，可以从存储在磁盘上的一组同源序列中任意成对比较多个序列，并且可以将包含同源性值百分比、不同核苷酸数量或KNUC值以及相应标准误差的矩阵发送到屏幕、打印机或磁盘。很快就会有一个程序，它使用从该矩阵推导出来的平均连锁聚类方法创建一个表示序列之间相似性的树状图。这些程序是用UCSD - PASCAL为苹果II计算机编写的，用TURBO - PASCAL为Sirius I/Victor 9000计算机编写的。
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