Division of Addiction Science, Treatment & Prevention, Department of Psychiatry, University of Colorado School of Medicine, Aurora, Colo. (Hinckley); Department of Psychiatry, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, Addiction Institute at Mount Sinai, New York (Ferland, Hurd).
Am J Psychiatry. 2024 May 1;181(5):353-358. doi: 10.1176/appi.ajp.20231006.
The increase of cannabis use, particularly with the evolution of high potency products, and of cannabis use disorder (CUD) are a growing healthcare concern. While the harms of adult use and potential medicinal properties of cannabis continue to be debated, it is becoming evident that adolescent cannabis use is a critical window for CUD risk with potential lifelong mental health implications. Herein, we discuss mental health consequences of adolescent cannabis use, factors that contribute to the risk of developing CUD, and what remains unclear in the changing legal landscape of cannabis use. We also discuss the importance of preclinical models to provide translational insight about the causal relationship of cannabis to CUD-related phenotypes and conclude with highlighting opportunities for clinicians and allied professionals to engage in addressing adolescent cannabis use.
大麻使用的增加，特别是随着高浓度产品的演变，以及大麻使用障碍（CUD）的增加，是一个日益严重的医疗保健问题。虽然成人使用大麻的危害和大麻的潜在药用特性仍在争论中，但越来越明显的是，青少年使用大麻是 CUD 风险的关键窗口，可能对终身心理健康产生影响。在此，我们讨论青少年使用大麻的心理健康后果、导致 CUD 风险的因素，以及在大麻使用不断变化的法律环境下仍不清楚的问题。我们还讨论了临床前模型的重要性，以提供关于大麻与 CUD 相关表型因果关系的转化见解，并以强调临床医生和相关专业人员参与解决青少年使用大麻的机会作为结论。
