Mohan Minnaladevi, Mannil Aruna, Chandrasekaran Venkatesh, Gulati Reena, Ganapathy Sachit, Nair Sreekumaran
Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Department of Biostatistics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Pediatr Pulmonol. 2023 Nov;58(11):3133-3138. doi: 10.1002/ppul.26633. Epub 2023 Aug 4.
Aquagenic wrinkling of palms (AWP) is emerging as a screening test for cystic fibrosis (CF). There is lack of normative data for the same in our population.
To generate normative data for AWP in children 1-15 years of age and to describe the factors associated with it.
Children aged 1-15 years were enrolled after obtaining informed consent and assent of the parent and child based on age. Information regarding age, gender, anthropometry, indications for visiting hospital and drug intake were noted down. Wrinkling test was done using distilled water maintained in room temperature. Sweat chloride analysis was done using Nano duct sweat analysis system for children having AWP within 3 min. The mean/median time to wrinkle was noted and presented as centile curves after smoothing.
The mean (SD) and median (interquartile range [IQR]) aquagenic wrinkling time in children 1-15 years of age was 4.88 (1.066) and 5 (4-5.75) minutes respectively. The mean (SD) and median (IQR) time for AWP was 4.78 (1.076) and 5 (4-5) minutes respectively for boys and 4.98 (1.048) and 5 (4-6) minutes, respectively for girls. The time taken to wrinkle was observed to increase with age. Males have earlier AWP than females. There was no association between AWP and anthropometry or sweat chloride levels.
We have estimated the normative data for AWP in children 1-15 years of age which can be used for CF screening in children with typical clinical features from resource limited settings.
掌部水致性皱纹（AWP）正逐渐成为囊性纤维化（CF）的一种筛查试验。在我们的人群中，缺乏关于该试验的规范性数据。
生成1至15岁儿童AWP的规范性数据，并描述与之相关的因素。
在获得基于年龄的家长和儿童的知情同意及同意后，纳入1至15岁的儿童。记录有关年龄、性别、人体测量学、就诊指征和药物摄入的信息。使用室温下的蒸馏水进行皱纹试验。对于在3分钟内出现AWP的儿童，使用纳米导管汗液分析系统进行汗液氯化物分析。记录皱纹出现的平均/中位数时间，并在平滑后以百分位数曲线呈现。
1至15岁儿童的平均（标准差）和中位数（四分位间距[IQR]）水致性皱纹时间分别为4.88（1.066）分钟和5（4 - 5.75）分钟。男孩的AWP平均（标准差）和中位数（IQR）时间分别为4.78（1.076）分钟和5（4 - 5）分钟，女孩分别为4.98（1.048）分钟和5（4 - 6）分钟。观察到皱纹出现的时间随年龄增加。男性的AWP比女性出现得早。AWP与人体测量学或汗液氯化物水平之间无关联。
我们已经估计了1至15岁儿童AWP的规范性数据，可用于对来自资源有限环境且具有典型临床特征的儿童进行CF筛查。
