Hayashi M, Kurihara J, Takahashi H, Machida M, Kobayashi M, Yamanaka H
Gan To Kagaku Ryoho. 1986 Mar;13(3 Pt 1):608-11.
The patient was a 26-year-old male. He was admitted to our hospital with a chief complaint of hemoptysis, cough and left scrotal mass on May 9,1984. Chest X-ray film, LAG and CT revealed multiple lung, lymph node and cerebral metastases. Based on a diagnosis of testicular neoplasm, orchiectomy was performed on May 14,1984. PVB chemotherapy (Cis-diamminedichloro-platinum, Vinblastine and Pepleomycin) was administered. Because he got worse, however, he was treated with another combination chemotherapy, consisting of Methotrexate (MTX, 100 mg/m2 intravenous push (i.v.), 200 mg/m2 12-h infusion, day 1. The dose of MTX was increased with each course. Maximum dose of MTX was 900 mg/m2/day), Vincristine (1.0 mg/m2 i.v. day 1.) Actinomycin D (10 micrograms/kg i.v. days 3.4.5), Cyclophosphamide (600 mg/m2 i.v. day 3.), Adriamycin (30 mg/m2 i.v. day 8.) and Melphalan (6 mg/m2 p.o. day 8.). After 6 courses of this regimen, distant metastases disappeared or were reduced to under one tenth, and complete remission was obtained without severe side effects. The patient was in good health on March 30, 1985.
患者为一名26岁男性。1984年5月9日因咯血、咳嗽和左侧阴囊肿块为主诉入院。胸部X光片、淋巴血管造影（LAG）和CT显示肺部、淋巴结和脑部有多处转移。基于睾丸肿瘤的诊断，于1984年5月14日行睾丸切除术。给予PVB化疗（顺二氯二氨铂、长春花碱和争光霉素）。然而，由于病情恶化，他接受了另一种联合化疗，包括甲氨蝶呤（MTX，100mg/m²静脉推注，200mg/m² 12小时输注，第1天。MTX剂量随疗程增加。MTX最大剂量为900mg/m²/天）、长春新碱（1.0mg/m²静脉注射，第1天）、放线菌素D（10μg/kg静脉注射，第3、4、5天）、环磷酰胺（600mg/m²静脉注射，第3天）、阿霉素（30mg/m²静脉注射，第8天）和马法兰（6mg/m²口服，第8天）。经过6个疗程的这种治疗方案后，远处转移消失或减少到十分之一以下，且获得了完全缓解，无严重副作用。1985年3月30日患者健康状况良好。
