揭示 TMEM106B：SARS-CoV-2 进入细胞的秘密通道。
Unveiling TMEM106B: SARS-CoV-2's secret entrance to the cell.
机构信息
Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
出版信息
Cell. 2023 Aug 3;186(16):3329-3331. doi: 10.1016/j.cell.2023.07.005.
The lysosomal membrane protein TMEM106B functions as a proviral factor in SARS-CoV-2 infection, though it was not known how. In this issue of Cell, Baggen et al. demonstrate that TMEM106B serves as an ACE2-independent receptor for SARS-CoV-2 entry by promoting the fusion of the viral membrane with the lysosomal membrane.
溶酶体膜蛋白 TMEM106B 在 SARS-CoV-2 感染中作为一种前病毒因子发挥作用，但具体机制尚不清楚。在本期《细胞》杂志中，Baggen 等人证明 TMEM106B 通过促进病毒膜与溶酶体膜融合，作为 SARS-CoV-2 进入的 ACE2 非依赖性受体。
Zotero 插件