Department of General Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China; Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, Changchun 130021, China.
Department of Colorectal & Anal Surgery, General Surgery Center, First Hospital of Jilin University, Changchun 130021, China.
Cytokine Growth Factor Rev. 2023 Oct;73:93-100. doi: 10.1016/j.cytogfr.2023.06.005. Epub 2023 Jul 1.
Neoplasms are one of the most concerned public health problems worldwide. Digestive system neoplasms, with a high morbidity and mortality, is one of the most common malignant tumors in human being. It is found that exosomes act as an intercellular communication media to carry the metabolic and genetic information of parental cells to target cells. Likely, exosomes participate in lipid metabolism and regulates multiple processes in digestive system neoplasms, including the information transmission among cancer cells, the formation of neoplastic microenvironment, and the neoplastic biological behaviors like metastasis, invasion, and the chemotherapy resistance. In this review, we firstly introduce the main mechanisms whereas exosomes act as intercellular lipometabolic communication mediator in digestive system neoplasms. Thereafter we introduce the relationship between exosomes lipid metabolism and various type of digestive system neoplasms, including gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer. Eventually, we summarized and prospected the development and implication of exosomes in digestive system neoplasms. The further research of exosomes as intercellular lipid metabolism mediator will contribute to accurate and efficient diagnosis and treatment of digestive system neoplasms.
肿瘤是全球最受关注的公共卫生问题之一。消化系统肿瘤是人类最常见的恶性肿瘤之一，其发病率和死亡率都很高。研究发现，外泌体作为一种细胞间通讯介质，将亲代细胞的代谢和遗传信息传递给靶细胞。外泌体可能参与脂质代谢，并调节消化系统肿瘤中的多种过程，包括癌细胞之间的信息传递、肿瘤微环境的形成，以及转移、侵袭和化疗耐药等肿瘤生物学行为。在这篇综述中，我们首先介绍了外泌体作为细胞间脂质代谢通讯介质在消化系统肿瘤中发挥作用的主要机制。然后，我们介绍了外泌体脂质代谢与各种类型的消化系统肿瘤（包括胃癌、肝癌、胰腺癌和结直肠癌）之间的关系。最后，我们总结并展望了外泌体在消化系统肿瘤中的发展和意义。对外泌体作为细胞间脂质代谢介质的进一步研究将有助于消化系统肿瘤的准确和有效诊断和治疗。
