嵌合抗原受体 T 细胞疗法治疗弥漫性中线胶质瘤。
CAR T cell therapies for diffuse midline glioma.
机构信息
Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine, and Wellbeing, University of Newcastle, Callaghan, NSW, Australia; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA; Department of Pediatrics, Stanford University, Stanford, CA, USA; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University, Stanford, CA, USA; Department of Neurosurgery, Stanford University, Stanford, CA, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.
出版信息
Trends Cancer. 2023 Oct;9(10):791-804. doi: 10.1016/j.trecan.2023.07.007. Epub 2023 Aug 3.
Diffuse midline glioma (DMG) is a fatal pediatric cancer of the central nervous system (CNS). The location and infiltrative nature of DMG prevents surgical resection and the benefits of palliative radiotherapy are temporary; median overall survival (OS) is 9-11 months. The tumor immune microenvironment (TIME) is 'cold', and has a dominant immunosuppressive myeloid compartment with low levels of infiltrating lymphocytes and proinflammatory molecules. Because survival statistics have been stagnant for many decades, and therapies targeting the unique biology of DMG are urgently needed, this has prompted the clinical assessment of chimeric antigen receptor (CAR) T cell therapies in this setting. We highlight the current landscape of CAR T cell therapy for DMG, the role the TIME may play in the response, and strategies to overcome treatment obstacles.
弥漫性中线脑胶质瘤（DMG）是一种致命的儿童中枢神经系统（CNS）癌症。DMG 的位置和浸润性使其无法进行手术切除，姑息性放疗的效果也是暂时的；中位总生存期（OS）为 9-11 个月。肿瘤免疫微环境（TIME）呈“冷”状态，具有占主导地位的免疫抑制性髓系细胞群，浸润淋巴细胞和促炎分子水平低。由于生存统计数据几十年来一直停滞不前，并且迫切需要针对 DMG 独特生物学的疗法，因此这促使人们在该领域评估嵌合抗原受体（CAR）T 细胞疗法。我们重点介绍了 CAR T 细胞疗法治疗 DMG 的现状，TIME 在反应中的作用以及克服治疗障碍的策略。
Zotero 插件