乳糜泻中针对麦胚凝集素的抗体。
Antibodies to wheat germ agglutinin in coeliac disease.
作者信息
Sollid L M, Kolberg J, Scott H, Ek J, Fausa O, Brandtzaeg P
出版信息
Clin Exp Immunol. 1986 Jan;63(1):95-100.
Abstract
Serum IgG and IgA antibodies to wheat germ agglutinin (WGA) were measured by an enzyme-linked immunosorbent assay (ELISA) with N-acetyl-D-glucosamine in all incubation steps to inhibit sugar-specific binding. Patients with coeliac disease (CD) had significantly higher antibody levels to WGA than patients with other intestinal disorders or healthy controls. Similar results were obtained for antibodies to the gluten fraction glyc-gli. The WGA antibodies did apparently not cross-react with gluten antigens, but commercial gluten powder contained traces of WGA or a similar lectin. Our findings support the proposal that WGA may be involved in the pathogenesis of CD.
摘要
通过酶联免疫吸附测定（ELISA）在所有孵育步骤中使用N-乙酰-D-葡萄糖胺来抑制糖特异性结合，测定血清中针对麦胚凝集素（WGA）的IgG和IgA抗体。与患有其他肠道疾病的患者或健康对照相比，乳糜泻（CD）患者针对WGA的抗体水平显著更高。对于麸质组分糖蛋白-麦醇溶蛋白的抗体也获得了类似结果。WGA抗体显然不会与麸质抗原发生交叉反应，但市售麸质粉含有痕量的WGA或类似凝集素。我们的研究结果支持WGA可能参与CD发病机制的观点。
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3
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