Williams J G, Deakin M, Ramage J K
Gut. 1986 Apr;27(4):428-32. doi: 10.1136/gut.27.4.428.
Intragastric pH was monitored during 24 hours in eight volunteers with duodenal ulcer disease in remission, while on placebo, cimetidine 400 mg bd, pirenzepine 50 mg bd, cimetidine 400 mg bd + pirenzepine 50 mg bd, cimetidine 200 mg bd + pirenzepine 25 mg bd. The control of intragastric acidity during the 24 hour period by the combination of low dose cimetidine and pirenzepine was significantly better than with cimetidine, or pirenzepine alone in full dosage. This difference was most apparent after breakfast but was still present after lunch when cimetidine had no significant effect. Combination treatment is a logical approach when continuous control of intragastric acidity is needed, but a three times daily regimen will be necessary to cover the 24 hours.
在八名十二指肠溃疡疾病已缓解的志愿者中，在服用安慰剂、西咪替丁400毫克每日两次、哌仑西平50毫克每日两次、西咪替丁400毫克每日两次加哌仑西平50毫克每日两次、西咪替丁200毫克每日两次加哌仑西平25毫克每日两次的情况下，监测了24小时的胃内pH值。低剂量西咪替丁和哌仑西平联合使用在24小时内对胃酸的控制明显优于单独使用全剂量的西咪替丁或哌仑西平。这种差异在早餐后最为明显，但在午餐后仍存在，此时西咪替丁没有显著效果。当需要持续控制胃酸时，联合治疗是一种合理的方法，但需要每日三次给药方案来覆盖24小时。
