哌仑西平与人用西咪替丁抗分泌活性的对照研究。
Antisecretory activity of pirenzepine versus cimetidine in man: a controlled study.
作者信息
Procacciante F, Citone G, Montesani C, Ribotta G
出版信息
Gut. 1984 Feb;25(2):178-82. doi: 10.1136/gut.25.2.178.
Antisecretory effect of single oral therapeutic doses of pirenzepine (25 mg and 50 mg) and cimetidine (200 mg and 400 mg) was studied in 12 patients with duodenal ulcer. Gastric secretion was studied in basal condition and after stimulation with pentagastrin. Basal, maximum and peak acid output, basal and maximum acidity, and basal and maximum volume were calculated after computerised correction for pyloric loss and duodenal reflux. Both drugs showed dose-related inhibition of all facets of gastric secretion. Cimetidine (200 mg) had a greater inhibitory effect on gastric basal secretion, but a similar effect on pentagastrin stimulated secretion as with pirenzepine (50 mg). Cimetidine (400 mg) showed about twice the inhibitory activity of pirenzepine (50 mg) both on basal and stimulated secretion.
在12例十二指肠溃疡患者中研究了单次口服治疗剂量的哌仑西平（25毫克和50毫克）和西咪替丁（200毫克和400毫克）的抗分泌作用。在基础状态下以及用五肽胃泌素刺激后研究胃分泌。在对幽门损失和十二指肠反流进行计算机校正后计算基础、最大和峰值酸输出、基础和最大酸度以及基础和最大体积。两种药物均显示出与剂量相关的对胃分泌各方面的抑制作用。西咪替丁（200毫克）对胃基础分泌的抑制作用更大，但对五肽胃泌素刺激分泌的作用与哌仑西平（50毫克）相似。西咪替丁（400毫克）在基础分泌和刺激分泌方面均显示出约为哌仑西平（50毫克）两倍的抑制活性。
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