Zhang Wenqian, Zha Kangkang, Hu Weixian, Xiong Yuan, Knoedler Samuel, Obed Doha, Panayi Adriana C, Lin Ze, Cao Faqi, Mi Bobin, Liu Guohui
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, 430022, China.
Biomater Res. 2023 Aug 4;27(1):76. doi: 10.1186/s40824-023-00411-9.
Various joint pathologies such as osteochondritis dissecans, osteonecrosis, rheumatic disease, and trauma, may result in severe damage of articular cartilage and other joint structures, ranging from focal defects to osteoarthritis (OA). The osteochondral unit is one of the critical actors in this pathophysiological process. New approaches and applications in tissue engineering and regenerative medicine continue to drive the development of OA treatment. Hydrogel scaffolds, a component of tissue engineering, play an indispensable role in osteochondral regeneration. In this review, tissue engineering strategies regarding osteochondral regeneration were highlighted and summarized. The application of hydrogels for osteochondral regeneration within the last five years was evaluated with an emphasis on functionalized physical and chemical properties of hydrogel scaffolds, functionalized delivery hydrogel scaffolds as well as functionalized intelligent response hydrogel scaffolds. Lastly, to serve as guidance for future efforts in the creation of bioinspired hydrogel scaffolds, a succinct summary and new views for specific mechanisms, applications, and existing limitations of the newly designed functionalized hydrogel scaffolds were offered.
各种关节疾病，如剥脱性骨软骨炎、骨坏死、风湿性疾病和创伤，可能导致关节软骨和其他关节结构的严重损伤，范围从局灶性缺损到骨关节炎（OA）。骨软骨单元是这一病理生理过程中的关键因素之一。组织工程和再生医学中的新方法和应用不断推动OA治疗的发展。水凝胶支架作为组织工程的一个组成部分，在骨软骨再生中发挥着不可或缺的作用。在这篇综述中，突出并总结了关于骨软骨再生的组织工程策略。评估了水凝胶在过去五年中用于骨软骨再生的应用，重点是水凝胶支架的功能化物理和化学性质、功能化递送水凝胶支架以及功能化智能响应水凝胶支架。最后，为了指导未来创建仿生水凝胶支架的工作，对新设计的功能化水凝胶支架的具体机制、应用和现有局限性提供了简要总结和新观点。
