Ying Haoli, Shen Chengchun, Pan Ruolang, Li Xiongfeng, Chen Ye
Department of Genetics, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Department of Genetic and Metabolic Disease, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Front Pharmacol. 2023 Apr 19;14:1152612. doi: 10.3389/fphar.2023.1152612. eCollection 2023.
Osteoarthritis (OA) is a kind of degenerative joint disease usually found in older adults and those who have received meniscal surgery, bringing great suffering to a number of patients worldwide. One of the major pathological features of OA is retrograde changes in the articular cartilage. Mesenchymal stromal cells (MSCs) can differentiate into chondrocytes and promote cartilage regeneration, thus having great potential for the treatment of osteoarthritis. However, improving the therapeutic effect of MSCs in the joint cavity is still an open problem. Hydrogel made of different biomaterials has been recognized as an ideal carrier for MSCs in recent years. This review focuses on the influence of the mechanical properties of hydrogels on the efficacy of MSCs in OA treatment and compares artificial materials with articular cartilage, hoping to provide a reference for further development of modified hydrogels to improve the therapeutic effect of MSCs.
骨关节炎（OA）是一种退行性关节疾病，常见于老年人和接受过半月板手术的人群，给全球众多患者带来巨大痛苦。OA的主要病理特征之一是关节软骨的逆行性改变。间充质基质细胞（MSCs）可分化为软骨细胞并促进软骨再生，因此在骨关节炎治疗方面具有巨大潜力。然而，提高MSCs在关节腔内的治疗效果仍是一个有待解决的问题。近年来，由不同生物材料制成的水凝胶已被公认为MSCs的理想载体。本文综述聚焦于水凝胶的力学性能对MSCs治疗OA疗效的影响，并将人工材料与关节软骨进行比较，希望为进一步开发改性水凝胶以提高MSCs的治疗效果提供参考。
