Centre for Bioseparation Technology (CBST), Vellore Institute of Technology (VIT), Tamilnadu, 632014, Vellore, India.
Mikrochim Acta. 2023 Aug 5;190(9):345. doi: 10.1007/s00604-023-05904-x.
For the first time a metal organic framework nanomaterial has been developed comprising manganese dioxide nanoparticle and iron and zinc metal ions interlinked with each other via terephthalic acid. The framework shape was identified as an elongated hexagonal nanorod (TEM) with varying functional groups (FT-IR) and diffraction patterns (XRD). The framework nanocomposite as such in aqueous acidic electrolyte solution has displayed an excellent conductivity (redox behavior) and surface excess (3.08 × 10 cm). Under the optimized conditions (0.1 M HSO as electrolyte, 50 mV/s scan rate, +1.26 V (vs Ag/AgCl)), the metal organic framework coated electrode has selectively identified vitamin D (VD) in the presence of various other interfering molecules and displayed excellent limit of detection (1.9 ng mL). The developed sensor has been applied to the determination of VD in extracted human plasma samples (RSD of 0.3-2.6 % and recovery of 96-102 %), and the obtained VD3 values are similar to HPLC-UV method.
首次开发了一种金属有机骨架纳米材料，它由二氧化锰纳米粒子和铁、锌金属离子通过对苯二甲酸相互连接而成。该骨架形状被确定为具有不同官能团（FT-IR）和衍射图案（XRD）的细长六方纳米棒（TEM）。在水溶液酸性电解质溶液中，这种骨架纳米复合材料具有优异的导电性（氧化还原行为）和表面过剩（3.08×10-2 cm）。在优化条件下（电解质为 0.1 M H2SO4，扫描速率为 50 mV/s，+1.26 V（相对于 Ag/AgCl）），金属有机骨架涂覆电极在存在各种其他干扰分子的情况下选择性地识别了维生素 D（VD），并显示出优异的检测限（1.9 ng mL）。该传感器已应用于提取的人血浆样品中 VD 的测定（RSD 为 0.3-2.6%，回收率为 96-102%），并获得了与 HPLC-UV 方法相似的 VD3 值。
