Spine and Osteopathy Ward, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning, 530021, Guangxi, China.
J Orthop Surg Res. 2023 Aug 5;18(1):574. doi: 10.1186/s13018-023-04051-6.
Osteoporosis affects more than 200 million women worldwide, with postmenopausal women being particularly susceptible to this condition and its severe sequelae disproportionately, such as osteoporotic fractures. To date, the current focus has been more on symptomatic treatment, rather than preventive measures. To address this, we performed a meta-analysis aiming to identify potential predictors of osteoporotic fractures in postmenopausal women, with the ultimate goal of identifying high-risk patients and exploring potential therapeutic approaches. We searched Embase, MEDLINE and Cochrane with search terms (postmenopausal AND fracture) AND ("risk factor" OR "predictive factor") in May 2022 for cohort and case-control studies on the predictors of osteoporotic fracture in postmenopausal women. Ten studies with 1,287,021 postmenopausal women were found eligible for analyses, in which the sample size ranged from 311 to 1,272,115. The surveyed date spanned from 1993 to 2021. Our results suggested that age, BMI, senior high school and above, parity ≥ 3, history of hypertension, history of diabetes mellitus, history of alcohol intake, age at menarche ≥ 15, age at menopause < 40, age at menopause > 50, estrogen use and vitamin D supplements were significantly associated with osteoporotic fracture in postmenopausal women. Our findings facilitate the early prediction of osteoporotic fracture in postmenopausal women and may contribute to potential therapeutic approaches. By focusing on preventive strategies and identifying high-risk individuals, we can work toward reducing the burden of osteoporosis-related fractures in this vulnerable population.
骨质疏松症影响着全球超过 2 亿的女性，其中绝经后女性尤其容易受到这种疾病及其严重后果的影响，例如骨质疏松性骨折。迄今为止，当前的重点更多地放在症状治疗上，而不是预防措施上。为了解决这个问题，我们进行了一项荟萃分析，旨在确定绝经后妇女骨质疏松性骨折的潜在预测因素，最终目的是确定高危患者并探索潜在的治疗方法。我们于 2022 年 5 月在 Embase、MEDLINE 和 Cochrane 中使用了（绝经后 AND 骨折）和（“风险因素”或“预测因素”）搜索词，以寻找关于绝经后妇女骨质疏松性骨折预测因素的队列和病例对照研究。我们发现了 10 项符合条件的研究，其中有 1287021 名绝经后女性符合分析条件，样本量从 311 到 1272115 不等。调查的日期从 1993 年到 2021 年不等。我们的研究结果表明，年龄、BMI、高中及以上学历、产次≥3、高血压病史、糖尿病病史、饮酒史、初潮年龄≥15 岁、绝经年龄<40 岁、绝经年龄>50 岁、雌激素使用和维生素 D 补充剂与绝经后妇女的骨质疏松性骨折显著相关。我们的发现有助于绝经后妇女骨质疏松性骨折的早期预测，并可能有助于潜在的治疗方法。通过关注预防策略和确定高危个体，我们可以努力减少这一脆弱人群中与骨质疏松相关的骨折负担。
