The First Affiliated Hospital of Gannan Medical University, Ganzhou, P.R. China.
Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, P.R. China.
Medicine (Baltimore). 2023 Aug 4;102(31):e34373. doi: 10.1097/MD.0000000000034373.
Diabetic retinopathy (DR) is one of the most common and serious microvascular complications of diabetes mellitus, the incidence of which has been increasing annually, and it is the main cause of vision loss in diabetic patients and a common cause of blindness. It is now found that thrombosis plays a crucial role in the disease progression in DR patients, and the final vision loss in DR may be related to the occurrence of thrombosis in the retinal vessels, which is dominated by abnormal endothelial cell function, together with platelet dysfunction, imbalance of coagulation and fibrinolytic function, and related alterations of inflammatory factors leading to the main cause of thrombotic disease in DR patients. In this review, we examine the role between DR and thrombosis and the association of each factor, including endothelial dysfunction; platelet dysfunction; coagulation-fibrinolytic imbalance; and alterations in inflammatory factors.
糖尿病视网膜病变（DR）是糖尿病最常见和最严重的微血管并发症之一，其发病率逐年增加，是糖尿病患者视力丧失的主要原因，也是失明的常见原因。现在发现，血栓形成在 DR 患者的疾病进展中起着至关重要的作用，DR 最终的视力丧失可能与视网膜血管发生血栓形成有关，其主要由内皮细胞功能异常，加上血小板功能障碍、凝血和纤溶功能失衡以及炎症因子的相关改变导致 DR 患者血栓性疾病的主要原因。在这篇综述中，我们检查了 DR 和血栓形成之间的作用以及每个因素之间的关联，包括内皮功能障碍；血小板功能障碍；凝血-纤溶失衡；和炎症因子的改变。
