Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
Department of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
Inflammopharmacology. 2023 Dec;31(6):3115-3125. doi: 10.1007/s10787-023-01306-w. Epub 2023 Aug 6.
Because of evident role of renin-angiotensin system in the etiology of rheumatoid arthritis, the current study's objective was to assess the anti-arthritic efficacy of ramipril through CFA-instigated arthritic model. The drug has been shown to have anti-inflammatory potential. CFA-instigated arthritic model assessed the anti-arthritic efficacy of ramipril by estimating different parameters, including paw volume, arthritic index scoring, haematological and biochemical attributes, histological and radiographic analyses, and various cytokines level. Ramipril significantly (p < 0.001) reduced paw volume and the arthritic index especially at the dose of 4mg/kg. The biochemical and haematological changes were likewise restored to normal by ramipril administration with an increase in anti-inflammatory cytokines while reducing pro-inflammatory cytokines level. Ramipril's ability to prevent arthritis by preserving the normal architecture of arthritis-induced joints is further supported by radiographic and histological investigation. The study's findings demonstrated ramipril's considerable anti-arthritic activity. To identify the precise mechanism of action, however, thorough mechanistic studies are still needed.
由于肾素-血管紧张素系统在类风湿关节炎的发病机制中起明显作用，本研究的目的是通过 CFA 诱导的关节炎模型评估雷米普利的抗关节炎疗效。该药物已显示出具有抗炎潜力。CFA 诱导的关节炎模型通过评估包括爪体积、关节炎指数评分、血液学和生化特性、组织学和放射学分析以及各种细胞因子水平在内的不同参数来评估雷米普利的抗关节炎疗效。雷米普利显著（p < 0.001）降低了爪体积和关节炎指数，尤其是在 4mg/kg 的剂量下。雷米普利还通过增加抗炎细胞因子和降低促炎细胞因子水平使生化和血液学变化恢复正常。雷米普利通过保护关节炎诱导关节的正常结构来预防关节炎的能力，通过放射学和组织学研究得到进一步支持。研究结果表明雷米普利具有相当的抗关节炎活性。然而，为了确定确切的作用机制，仍需要进行深入的机制研究。
