炎症标志物及其与肌肉力量和质量的关系：系统评价和荟萃分析。
Markers of inflammation and their association with muscle strength and mass: A systematic review and meta-analysis.
机构信息
Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Victoria, Australia.
Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Victoria, Australia; Department of Human Movement Sciences, @AgeMelbourne, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.
出版信息
Ageing Res Rev. 2020 Dec;64:101185. doi: 10.1016/j.arr.2020.101185. Epub 2020 Sep 26.
BACKGROUND
Chronic inflammation has been associated with sarcopenia and its components skeletal muscle strength and muscle mass. The aim of this systematic review and meta-analysis was to determine the relationship between systemic inflammation, muscle strength and/or muscle mass in adults.
METHODS
An electronic search using keywords such as 'acute phase proteins, cytokines and sarcopenia, muscle mass, muscle strength' was conducted via Pubmed, Web of Science and Embase from inception until the 30th of June 2020. A meta-analysis using correlation data was performed to determine the overall relationship between inflammation and muscle strength and muscle mass in adults.
RESULTS
Overall, 168 articles; 149 cross-sectional articles (n = 76,899 participants, 47.0 % male) and 19 longitudinal articles (n = 12,295 participants, 31.9 % male) met inclusion criteria. Independent of disease state, higher levels of C reactive protein (CRP), Interleukin (IL)-6 and Tumor necrosis factor (TNF)α were associated with lower handgrip and knee extension strength (CRP; r = -0.10, p < 0.001, IL-6; r = -0.13, p < 0.001, TNFα; r = -0.08, p < 0.001 and CRP; r = -0.18, p < 0.001, IL-6; r = -0.11, p < 0.001, TNFα; r = -0.13, p < 0.001 respectively) and muscle mass (CRP; r = -0.12, p < 0.001, IL-6; r = -0.09, p < 0.001, TNFα; r = -0.15, p < 0.001). Furthermore, higher levels of systemic inflammatory markers appeared to be associated with lower muscle strength and muscle mass over time.
CONCLUSION
Higher levels of circulating inflammatory markers are significantly associated with lower skeletal muscle strength and muscle mass.
背景
慢性炎症与肌肉减少症及其组成部分（骨骼肌力量和肌肉质量）有关。本系统评价和荟萃分析的目的是确定成年人全身炎症、肌肉力量和/或肌肉质量之间的关系。
方法
通过 Pubmed、Web of Science 和 Embase 使用关键词（如“急性期蛋白、细胞因子和肌肉减少症、肌肉质量、肌肉力量”）进行电子检索，检索时间从建库至 2020 年 6 月 30 日。使用相关数据进行荟萃分析，以确定炎症与成年人肌肉力量和肌肉质量之间的总体关系。
结果
总共纳入 168 篇文章；149 篇横断面研究文章（n = 76899 名参与者，47.0%为男性）和 19 篇纵向研究文章（n = 12295 名参与者，31.9%为男性）符合纳入标准。独立于疾病状态，较高水平的 C 反应蛋白（CRP）、白细胞介素（IL）-6 和肿瘤坏死因子（TNF）α与较低的握力和膝关节伸展力量相关（CRP；r = -0.10，p < 0.001，IL-6；r = -0.13，p < 0.001，TNFα；r = -0.08，p < 0.001 和 CRP；r = -0.18，p < 0.001，IL-6；r = -0.11，p < 0.001，TNFα；r = -0.13，p < 0.001）和肌肉质量（CRP；r = -0.12，p < 0.001，IL-6；r = -0.09，p < 0.001，TNFα；r = -0.15，p < 0.001）。此外，较高水平的系统性炎症标志物似乎与随时间推移肌肉力量和肌肉质量的下降有关。
结论
循环炎症标志物水平升高与骨骼肌力量和肌肉质量降低显著相关。
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